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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Cluster-based anonymity model and algorithm for 1:1 dataset with a single sensitive attribute using machine learning technique
منشور في 2024"…Cluster Based anonymity model measured the utility loss for all the attributes and the average utility loss for the anonymized patient dataset is 3.78%.…"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Accelerating the Design of Photocatalytic Surfaces for Antimicrobial Application: Machine Learning Based on a Sparse Dataset
منشور في 2021"…Using an experiment-to-machine-learning scheme applied to a limited experimental dataset, we built a model that can predict the photocatalytic activity of materials for antimicrobial applications over a wide range of material compositions. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Novel interpretable and robust web-based AI platform for phishing email detection
منشور في 2024"…Utilizing a comprehensive and largest available public dataset, the model achieves a f1 score of 0.99 and is designed for deployment within relevant applications. …"
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Image-Based Air Quality Estimation Using Convolutional Neural Network Optimized by Genetic Algorithms: A Multi-Dataset Approach
منشور في 2025"…To mitigate overfitting, we implemented dropout layers, batch normalization, and early stopping, significantly enhancing the model’s generalization capability. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Variable Selection in Data Analysis: A Synthetic Data Toolkit
منشور في 2024"…Variable (feature) selection plays an important role in data analysis and mathematical modeling. This paper aims to address the significant lack of formal evaluation benchmarks for feature selection algorithms (FSAs). …"
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A Neighborhood Framework for Resource-Lean Content Flagging
منشور في 2022"…<p dir="ltr">We propose a novel framework for cross- lingual content flagging with limited target- language data, which significantly outperforms prior work in terms of predictive performance. …"
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Conceptual modeling of a reactor bed of a nickel-copper bi-metallic catalyst for dry reforming of methane
منشور في 2023"…The developed kinetics model and the associated characterization dataset could be used for future scalability/reproducibility assessments.…"
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Data-Driven Electricity Demand Modeling for Electric Vehicles Using Machine Learning
منشور في 2024احصل على النص الكامل
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Label dependency modeling in Multi-Label Naïve Bayes through input space expansion
منشور في 2024"…We subject our enhanced iMLNB model to a rigorous empirical evaluation, utilizing six benchmark datasets. …"