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يعرض 1 - 20 نتائج من 538 نتيجة بحث عن '(( significantly increased decrease ) OR ( significant potential drug ))', وقت الاستعلام: 0.10s تنقيح النتائج
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    Factors Influencing the Magnitude and Clinical Significance of Drug Interactions Between Azole Antifungals and Select Immunosuppressants حسب Saad, Aline

    منشور في 2006
    "…Differences in metabolism and in the inhibitory potency of cytochrome P450 3A4 and Pglycoprotein influence the onset, magnitude, and resolution of drug interactions and their potential effect on clinical outcomes. …"
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    article
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    Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer حسب Sourour Idoudi (14153457)

    منشور في 2022
    "…<p>There is growing concern in the rise of colorectal cancer (CRC) cases globally, and with this rise is the presentation of drug resistance. Like other cancers, current treatment options are either invasive or manifest severe side effects. …"
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    The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... حسب Wesal Habbab (17346961)

    منشور في 2019
    "…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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    The Role of AI in Drug Discovery حسب M. K. G. Abbas (18021646)

    منشور في 2024
    "…By offering a comprehensive overview of AI′s role in drug discovery, this paper underscores the technology‘s potential to significantly enhance drug development, while also acknowledging the hurdles that must be overcome to fully realize its benefits.…"
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    Antifungal potential of plant-based extracts against <i>Candida</i> species: values, safety concerns, and possible applications حسب Atefeh Esmaeili (462337)

    منشور في 2025
    "…The overuse and inappropriate application of conventional antifungal drugs have contributed to frequent treatment failures and the alarming rise of drug-resistant strains, prompting a growing interest in exploring naturally derived alternatives. …"
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    A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

    منشور في 2024
    "…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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    Promising approaches for controlled pulmonary drug delivery حسب Nature Research (16552612)

    منشور في 2015
    "…Micro- and nanoparticles-based drug delivery systems could potentially improve the delivery of inhaled drugs significantly, because they can be designed in specific shapes and sizes, and with certain other properties that optimize their bioavailability. …"
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    Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex حسب Wesam S. Ahmed (10170053)

    منشور في 2022
    "…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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    Machine Learning Techniques for Pharmaceutical Bioinformatics حسب SULTAN, AHMED ATTA AHMED

    منشور في 2018
    "…DDIs network has a significant role in drug repurposing; it uncovers the hidden properties of the drug behavior. …"
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    Deep Learning for the Accurate Prediction of Triggered Drug Delivery حسب Husseini, Ghaleb

    منشور في 2024
    "…The deep learning-based predictions significantly outperform linear predictions, proving the utility of advanced computational methods in drug delivery. …"
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    Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion حسب Khoury, Nathalie

    منشور في 2014
    "…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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    article