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Facile Ultrasound-Triggered Release of Calcein and Doxorubicin from Iron-Based Metal-Organic Frameworks
منشور في 2020"…DOX encapsulation efficiency and capacity were found to be 16.10% and 13.37 wt.%, respectively. In-vitro release experiments demonstrated significant release, reaching 80% in 245 minutes, under acoustic irradiation, compared to around 6% in the absence of US. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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pH and ultrasound dual-responsive drug delivery system based on PEG–folate-functionalized Iron-based metal–organic framework for targeted doxorubicin delivery
منشور في 2021"…The results confirmed the sonosensitivity of the nanovehicles, with US-triggered release efficiency reaching up to 90% after 280 min (at a pH of 5.3). …"
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High-amylose carboxymethyl starch matrices for oral sustained drug-release
منشور في 2016"…Amylose-based polymers are normally subject to biodegradation by α-amylase enzymes present in the gastrointestinal tract, but matrix systems show no significant degradation of tablets by α-amylase in vitro. …"
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Propagation and deposition of non-circular finite release particle-laden currents
منشور في 2015"…The dynamics of non-axisymmetric turbidity currents is considered here for a range of Reynolds numbers of O (104) when based on the initial height of the release. The study comprises a series of experiments and highly resolved simulations for which a finite volume of particle-laden solution is released into fresh water. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Functionalized Metal Organic Frameworks For Chemotherapy Drug Delivery
منشور في 2020احصل على النص الكامل
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A Probabilistic and Traffic-Aware Bundle Release Scheme for Vehicular Intermittently Connected Networks
منشور في 2012"…These distributions constitute the basis of a novel Probabilistic Bundle Release Scheme with Bulk Bundle Release (PBRS-BBR) that is proposed with the objective to minimize the average bundle delivery delay. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Comparative study of LNG, liquid hydrogen, and liquid ammonia post-release evaporation and dispersion during bunkering
منشور في 2024"…The flammable vapour clouds of LNG and LH2 remain within the main deck area, whereas the toxic gas cloud of LNH3 disperses towards the shore and spreads near the ground on the shore side. Based on the dispersion behaviours, the hazards of LNG and LH2 are comparable, while LNH3 poses significantly higher hazards. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Enhancing Curcumin’s therapeutic potential in cancer treatment through ultrasound mediated liposomal delivery
منشور في 2024"…CLs were effectively prepared with particles sized at 81 ± 2 nm, demonstrating stability and controlled release of curcumin under ultrasound exposure. In vitro studies using HCC1954 cells, the combination of CLs, ultrasound, and Definity microbubbles significantly improved curcumin’s anti-tumor effects, particularly under specific conditions: 15 s of continuous ultrasound at 0.12 W/cm² power density with 0.6 × 10⁷ microbubbles/mL. …"
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Advanced monolayer and layer-by-layer nanocapsule systems for sustained release of carvacrol and trans-cinnamaldehyde against multidrug-resistant <i>Salmonella</i> in poultry
منشور في 2025"…While several studies have evaluated free trans-cinnamaldehyde and carvacrol, there is a notable lack of research on encapsulated forms, using different types of capsules for controlled release of these antimicrobials in food applications. …"