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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Designing a Flexible and Reconfigurable Manufacturing System Considering a Circular Shaped Layout
منشور في 2018احصل على النص الكامل
doctoralThesis -
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Engineering PLA-MXene nanocomposite with balanced mechanical properties for enhanced shape memory effect
منشور في 2024"…The PLA/Mx composite exhibited a significantly improved shape memory effect than the PLA alone. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Role of Active Morphing in the Aerodynamic Performance of Flapping Wings in Formation Flight
منشور في 2021"…This arrangement enables an increase in the overall efficiency of the group because the wake vortices shed by each of the birds provide additional lift and thrust to every member. …"
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Double diffusive mixed convection and entropy generation analysis of NEPCM-water mixture in a π-shaped cavity
منشور في 2025"…Results demonstrate that Reynolds and Richardson numbers significantly enhance heat and mass transfer (up to 204 % increase in Nusselt number), while magnetic fields substantially suppress convective transport (60.5 % reduction in Nusselt number). …"
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Design, Implementation, and Performance Analysis of Actively
منشور في 2023احصل على النص الكامل
doctoralThesis -
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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FEA Investigation of Elastic Buckling for Functionally Graded Material (FGM) Thin Plates with Different Hole Shapes under Uniaxial Loading
منشور في 2022"…Moreover, the lower the power law index, the higher the critical buckling load. The diamond shape opening shows the best performance in terms of the critical buckling load, and the effect of the plate thickness has a more significant influence on the critical buckling load of the FGM plate compared to the size of the opening.…"
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Enhanced natural convection in a U-shaped baffled cavity: Synergistic effects of magnetic fields and wall oscillations on Nano-encapsulated PCM
منشور في 2025"…Nanoparticle volume fraction also significantly enhances heat transfer, with a 58.9 % increase in Nusselt number as <i>ϕ</i> increases from 0.01 to 0.04. …"
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Numerical Investigation of Flexural Behavior of Reinforced Concrete (RC) T-Beams Strengthened with Pre-Stressed Iron-Based (FeMnSiCrNi) Shape Memory Alloy Bars
منشور في 2023"…Based on the numerical results, it was found that increasing the compression strength from 30 to 60 MPa slightly improves the beam’s strength (by 2%), but it significantly increases its ductility by approximately 45%. …"
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CFD modeling of particle settling in drilling fluids: Impact of fluid rheology and particle characteristics
منشور في 2021"…Ellipsoidal cuttings exhibited significantly greater resistance to settling as compared to spherical particles, mainly due to the increased drag force. …"