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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Variation in Seasonal Precipitation over Gaza (Palestine) and Its Sensitivity to Teleconnection Patterns
منشور في 2021"…Based on rainfall records during 1974–2016 at seven meteorological stations in the Gaza region, this study aims to (1) analyze the observed SP trend over the Gaza region, and (2) examine the SP sensitivity to climate indices. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Seasonal and spatial variations in concentration, diversity, and antibiotic resistance of ambient bioaerosols in an arid region
منشور في 2024"…Spatial and seasonal variations significantly impacted microbial concentrations, with the highest average concentrations observed at 514 ± 77 CFU/m<sup>3</sup> for bacteria over the dry-hot summer season and 134 ± 31 CFU/m<sup>3</sup> for fungi over the mild winter season. …"
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Monitoring the variation of soil quality with sewage sludge application rates in absence of rhizosphere effect
منشور في 2020"…Besides, analytical results and field observations revealed no trends of soil salinization or acidification by excessive sludge amounts. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Ribosomal DNA Copy Number Variation is Coupled with DNA Methylation Changes at the 45S rDNA Locus
منشور في 2023"…Using this approach, we observed high inter-individual variation in rDNA CN, and limited intra-individual copy differences in several post-mortem tissues. …"
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Procedural Variation in Pars Plana Vitrectomy for the Management of Rhegmatogenous Retinal Detachment: A Retrospective Cohort Study
منشور في 2025"…The choice of gas tamponade showed a significantly better BCVA at 0.37 + 0.41 LogMAR. Combined phacoemulsification with Intraocular lens (IOL) implantation and vitrectomy do not significantly affect the overall success of the operation. …"
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A population study of clinically actionable genetic variation affecting drug response from the Middle East
منشور في 2022"…Distinct distribution of actionable pharmacogenomic variation was also observed among the Qatari subpopulations. …"