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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Characterization of the dynamic flow response in microfluidic devices
منشور في 2024احصل على النص الكامل
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Short-term behavioural responses to thermal stress by hawksbill turtles in the Arabian region
منشور في 2014"…Swim speeds were significantly higher and orientation was less omnidirectional during the migrations than when foraging. …"
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G7 currencies in the oil storm: A deep dive into shock responses
منشور في 2026"…G7 countries accounted for approximately 53% of the world's petroleum consumption; thus, shocks to the oil market have significant economic implications. To this end, we investigate the responses of G7 real effective exchange rates (REERs) to oil supply, demand, and risk shocks across various economic circumstances. …"
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Effectiveness of Positron Emission Tomography for Predicting Chemotherapy Response in Colorectal Cancer Liver Metastases
منشور في 2010"…Transcutaneous ultrasonography is even less invasive but often less accurate.9 Finally, positron emission tomography (PET) using fluorine-18–labeled deoxyglucose detects increased metabolic activity (uptake). …"
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Waste-derived activated carbons for effective adsorptive removal of strontium, barium, and binary pollutants: A response surface methodology study
منشور في 2024"…The results revealed that only temperature and dosage show significant effects on the responses and that optimum values of the selected parameters were obtained by solving the prediction equations, which were validated with less than 4 % error %. …"
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Automated inferior vena cava distensibility index for assessing fluid responsiveness in ventilated patients after cardiac surgery: a prospective pilot comparative study
منشور في 2025"…</p><h3>Conclusions</h3><p dir="ltr">Among cardiac surgical patients, manual IVC-DI correlated significantly with SVV in assessing fluid responsiveness. …"
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Accessibility first: detecting frustration in web browsing for visually impaired and sighted smartphone users
منشور في 2023"…When VI participants experienced a session timeout, they significantly showed a higher level of arousal. When comparing the physiological responses of sighted and VI participants in the page refresh and session timeout tasks, the results show that the arousal level is significantly higher in VI participants, primarily due to accessibility issues.…"
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Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination
منشور في 2024"…</p><h3>Results</h3><p dir="ltr">Homologous primary vaccination with ChAdOx1 not only showed less potent NTAb, TAb, anti‐S‐RBD IgG, and anti‐S1 IgA immune responses compared to primary BNT162b2 or mRNA‐1273 vaccination regimens (<i>p</i> < 0.05) but also showed ~3‐fold less anti‐S1 IgA response compared to infection‐induced immunity (<i>p</i> < 0.001). …"
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Dynamic Change in Insulin Resistance Induced by Free Fatty Acids Is Unchanged Though Insulin Sensitivity Improves Following Endurance Exercise in PCOS
منشور في 2018"…Compared to saline, lipid infusion lowered the rate of insulin stimulated glucose disposal (M value; mg/kg/min) by 67 ± 5% (from 0.5 ± 0.03 to −0.25 ± 0.2, p = 0.01) in PCOS, and by 49 ± 7% (from 0.65 ± 0.06 to 0.3 ± 0.1, p = 0.01) in controls. The M value was significantly less in PCOS compared to controls for both saline (p < 0.01) and lipid (p < 0.05). …"