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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Treatment of acute Mania. (c1999)
منشور في 1999"…Background: Bipolar disorder is a relatively common disorder and is characterized by "unpredictable swings in mood from mania to depression". Mania is a disease state which induces difficulties in work performance and psychosocial functioning requiring rapid and effective treatment in order to allow the patients to return to nonnal function. …"
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masterThesis -
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Kounis syndrome: acute myocardial injury triggered by ant bite-induced anaphylaxis
منشور في 2025"…Electrocardiography revealed transient widespread ST depression and ST elevation in lead aVR, a pattern reflecting global ischemia, which is uncommon in Kounis syndrome. …"
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Potential Therapeutic Effects of Lebanese Cannabis oil in Female Mouse Models of Neuropsychiatric Disorders
منشور في 2022"…The results showed that intraperitoneal injections of Lebanese Cannabis oil at doses of 5 mg/kg and 20 mg/kg rescued depression-like behaviors induced by the CVS. Therefore, Cannabis oil significantly rescues social avoidance behavior and promotes social interaction. …"
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masterThesis -
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Evaluation of the Effect of <i>Hypericum triquetrifolium</i> Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF
منشور في 2020"…<h3>Background</h3><p dir="ltr">Chronic psychosocial stress impairs memory function and leads to a depression-like phenotype induced by a persistent status of oxidative stress. …"
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Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling
منشور في 2020"…Even though WTS initially decreased anxiety-like behaviors, prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. …"
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Brain Connectivity Analysis Under Semantic Vigilance and Enhanced Mental States
منشور في 2019"…BRMUS factors, such as fatigue, depression, and anger, significantly decrease in the enhancement group compared to vigilance group. …"
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The combinatory effects of diet and exercise on BDNF gene expression
منشور في 2017"…Results showed that supplementation with 1.5% leucine significantly induced BDNF in the brain, and this effect was additive with exercise as well. …"
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
منشور في 2017"…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …"
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Waterpipe Tobacco Smoke Nicotine Mediates Resilience to Chronic Stress by Activating BDNF Signaling
منشور في 2020"…Even though initially, WTS decreased anxiety-like behaviors it was found that prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. …"
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masterThesis -
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Renewable Energy, Coal as a Baseload Power Source, and Greenhouse Gas Emissions: Evidence from U.S. State-Level Data
منشور في 2017"…It is estimated that a 10% increase in the share of renewable energy could decrease CH4 emissions by about 0.26%. …"
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article