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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Growth hormone treatment modulates active ghrelin levels in rats
منشور في 2014"…Genotropin treatment caused a dose dependent decrease in active ghrelin concentration in stomach, kidney and pancreas with a concomitant increase in plasma, and reaching significance at 20 and 100 µg/rat/day doses. …"
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Direct Oral Anticoagulants Compared to Warfarin in Patients with Intermediate‐ to High‐Risk Pulmonary Embolism: A Systematic Review and Meta‐Analysis
منشور في 2025"…There was no significant difference in the safety outcomes (major and minor bleeding events), with a trend towards a decreased risk among direct oral anticoagulant treated cohorts (OR 0.3, 95% CI 0.08–1.1) and (OR 0.64, 95% CI 0.24–1.7), respectively.…"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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3D printing of circular materials: Comparative environmental analysis of materials and construction techniques
منشور في 2023"…The main environmental "hot spot" identified for the geopolymer-based 3D printed construction process was the amount of electrical energy required for the mechanical processing of waste materials, which was more than 61% of the total GWP impact. In addition to decreasing solid CDW, the developed approach has significant potential for improvement by using more sustainable energy sources and reducing the amount of solid CDW generated.…"
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Adult appendicitis score versus Alvarado score: A comparative study in the diagnosis of acute appendicitis
منشور في 2023"…It requires proper management to decrease mortality and morbidity. Clinical scoring systems for diagnosing AA aimed to decrease the use of radiological scans and the rate of negative appendectomies (NA). …"
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Comparative Effect of Sodium Butyrate and Sodium Propionate on Ovarian Cancer Migration, Invasion, and Epithelial-To-Mesenchymal Transition
منشور في 2025"…Finally, our results revealed a significant decrease in the ratios of P-ERK/ERK and P-MEK/MEK following treatment. …"
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EEG-Based Semantic Vigilance Level Classification Using Directed Connectivity Patterns and Graph Theory Analysis
منشور في 2020"…The strength and directionality of information flow in the connectivity network by RWTE/PDC and the GTA measures significantly decrease with vigilance decrement, p<0.05. …"
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Intravenous administration of gold nanoparticles in rats exhibit alterations in sphingomyelins, bile acids, sphingolipids, and cholesterol esters levels
منشور في 2024"…Furthermore, treatment with AuNPs caused significant alterations in cholesterol ester levels, essential for lipid storage and transport, indicating disruptions in these mechanisms. …"
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3D Concrete Printing Sustainability: A Comparative Life Cycle Assessment of Four Construction Method Scenarios
منشور في 2020"…The LCA analysis showed that 3DCP significantly reduced environmental effects in terms of global warming potential (GWP), acidification potential (AP), eutrophication potential (EP), smog formation potential (SFP), and fossil fuel depletion (FFD), as compared to conventional construction methods. …"
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Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response
منشور في 2019"…Kaplan–Meier analysis indicated that patients who received NAC cycles and their excised tumors remained with high levels of NRP-1 had a lower overall survival compared with patients whose tissue NRP-1 decreased post-NAC (log-rank <i>p</i> = 0.049). …"
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Renewable Energy, Coal as a Baseload Power Source, and Greenhouse Gas Emissions: Evidence from U.S. State-Level Data
منشور في 2017"…After accounting for the role of coal as a baseload power source, an increase in the share of renewable energy is estimated to mitigate N2O emissions at the U.S. state level only if states individually decrease their share of coal use to levels below 41.47%. …"
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Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats
منشور في 2020"…Equally, it showed a rise of the apoptotic markers (a decrease in the expression of the Bcl-2 and an increase of the P53). …"