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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Development, Characterization and In Vitro Evaluation of Cannabidiol Loaded Zeolite Nanoparticles
منشور في 2025"…In addition, Cell Uptake studies demonstrated an increase in CBD internalization and retention by 2.4 folds for the USY loaded zeolite and 1.9 folds for the MCM-41 loaded zeolite when compared to CBD in its free form. …"
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Optimal Planning of Distributed Generators and Shunt Capacitors in Isolated Microgrids With Nonlinear Loads
منشور في 2020"…The effectiveness of the proposed planning approach has been validated using the PG&E 69-bus system, and the followings are observed: 1) the significance of applying suitable fundamental-power-flow and harmonic-power-flow algorithms for isolated microgrids, and 2) the possibility of avoiding a severe voltage distortion by utilizing an appropriate planning method and only small increase in the cost.…"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Behavior Of Reinforced Concrete Columns Embedded with PET Bottles Under Concentric Axial Compression
منشور في 2025احصل على النص الكامل
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Effect of Girder Damage on the Structural Behavior of Slab-on-Girder Bridges
منشور في 2011احصل على النص الكامل
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Comparative Study of the Structural Behaviour of Cast Acrylic & Laminated Glass Under the Impact of Dynamic Loading in Aquatic Applications
منشور في 2023"…Finally, CA sheets recorded slightly lower deflection values than it was in LG under the increasing effect of hydrostatic pressure (collision depth) and eventually showed almost a constant behavior of stress but significantly lower than those recorded in LG sheets.…"
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Electric Vehicles Charging Station Load Forecasting Integration With Renewable Energy Using Novel Deep EfficientBiLSTMNet
منشور في 2025"…<p dir="ltr">The exponential increase in the adoption of Electric Vehicles (EVs) presents significant problems to the stability of the power grid. …"
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FEA Investigation of Elastic Buckling for Functionally Graded Material (FGM) Thin Plates with Different Hole Shapes under Uniaxial Loading
منشور في 2022"…The results show that the increase in the size of the opening and the aspect ratio reduces the critical buckling load of the FGM plate. …"
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Urban Geometry: The Effect of Height Diversity and Buildings Configuration on Thermal Performance and Cooling Load at Urban Scale. A Case Study in Dubai / UAE
منشور في 2018"…The research found that a significant variation in building height reduces the cooling load more than a gradual height variation, and consequently offers more energy saving. …"
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