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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Country of birth affects blood pressure in the French hypertensive diabetic population
منشور في 2015"…In a population of 56,242 individuals living in France, we showed that individuals born in France have significantly different levels of blood pressure (BP) and cardiovascular (CV) risk factors than African and Asian populations born in their own country but living long-term in France (average duration of stay, 5–10 years). …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Impact of the positive pressure valve on vascular access device occlusions and bloodstream infections
منشور في 2009"…Background/Purpose The use of needleless positive pressure connector valves (PPVs) on venous access devices (VADs) has been shown to have possible benefits in decreasing VAD occlusion rates. …"
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Impact of miscuffing during home blood pressure measurement on the prevalence of masked hypertension
منشور في 2013"…Hypertension status differed significantly between standard vs. large cuffs: sustained hypertension (56.6% vs. 41.5%, respectively; P = 0.002), controlled hypertension (20.8% vs. 28.3%, respectively; P = 0.04), white coat hypertension (7.5% vs. 22.6%, respectively; P = 0.002), masked hypertension (15.1% vs. 7.5%, respectively; P = 0.04). …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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The effect of a patient centred care bundle intervention on pressure ulcer incidence (INTACT): A cluster randomised trial
منشور في 2016"…Conclusions Although the pressure ulcer prevention care bundle was associated with a large reduction in the hazard of ulceration, there was a high degree of uncertainty around this estimate and the difference was not statistically significant. …"
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Intraocular pressure trends following intravitreal injections of anti-VEGF agents for diabetic macular edema
منشور في 2013"…Although there was no significant difference in the baseline IOPs betweenthe IOP rise group (mean 15.76 ; SD=3.18) vs. the rest of the eyes (mean 17.34 (SD= 3.48), p: 0.071), final IOP was significantly higher in the IOP rise group (mean 18.65 vs.16.81, p 0.047). …"
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ExoventQ: A Novel Low-Cost Portable Negative Pressure Ventilator Design and Implementation
منشور في 2024"…This prompted investigations into developing new, cost-effective methods for producing ventilators. Different types of ventilators, such as positive pressure ventilators (PPVs), conventional negative pressure ventilators (NPVs), and biphasic cuirass ventilators (BCVs), were considered. …"
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Assessing the Effects of Music on Anxiety and Performance in Tasks Using Heart Rate Variability and Mean Arterial Pressure
منشور في 2024"…The effect of music (weightless music and Kaapi raga) on cardiovascular parameters in anxiety disorders participants was examined while listening to music and performing an attention-based task by measuring electrocardiogram (ECG) and Mean Arterial Pressure (MAP). A comparison of MAP between weightless music and the Kaapi group did not show statistically significant differences, however, changes were noted within both groups. …"
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Driving against the clock: Investigating the impacts of time pressure on taxi and non-professional drivers’ safety and compliance
منشور في 2024"…The findings reveal that drivers exhibited significantly riskier behaviors under time pressure, including higher speeds and reduced adherence to traffic rules. …"
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Semi-analytical Model to Predict Dynamic Capillary Pressure–Saturation Relationship for Flows in Heterogeneous Porous Media
منشور في 2024"…<p dir="ltr">The capillary pressure defines pressure difference between non-wetting and wetting fluids. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Transfer function analysis between arterial pressure and renal sympathetic nerve activity at cardiac pacing frequencies in the rat
منشور في 2007"…Cardiac pacing slightly increased mean AP (0.8 ± 0.2 mmHg/Hz) and decreased pulse pressure (−3.6 ± 0.3 mmHg/Hz) while leaving the mean level of RSNA essentially unaltered (P = 0.680, repeated-measures ANOVA). …"
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Nitinol Stents: A Finite Element Analysis of their Interaction with the Wall of Blood Vessels
منشور في 2023احصل على النص الكامل
doctoralThesis