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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B
منشور في 2020"…EMD or CA-074Me prevented the dispersal of the lysosomes induced by Ang II and reduced the ratio of LC3-II to LC3-I, a marker of autophagy. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Modelling the utilization rates of pedestrian crosswalks
منشور في 2023"…A zebra crossing is a form of pedestrian crossing provision point on roads that have significant volumes of traffic. It is one of the safety measures employed to reduce avoidable pedestrian-motorist conflicts and accidents on such roads. …"
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Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials
منشور في 2023"…</p><h3>Methods</h3><p dir="ltr">We conducted a systematic review, meta‐analysis, and meta‐regression following searches in major scientific databases for clinical trials investigating the effect of pro/pre/synbiotics on lipid profile published until April 2022. …"
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Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study
منشور في 2022"…We found a significant association between high pSAA activity, but not AMY1 CNV, and reduced odds of diabetes in Qatari women. …"
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Anti-hypertrophic effect of Na<sup>+</sup>/H<sup>+</sup> exchanger-1 inhibition is mediated by reduced cathepsin B
منشور في 2020"…EMD or CA-074Me prevented the dispersal of the lysosomes induced by Ang II and reduced the ratio of LC3-II to LC3-I, a marker of autophagy. …"
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Elevated levels of salivary α- amylase activity in saliva associated with reduced odds of obesity in adult Qatari citizens: A cross-sectional study
منشور في 2022"…The mean and median ssAAa were significantly lower in obese individuals. There were significant inverse associations between ssAAa and BMI, and fat mass. …"
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Discovery of a novel cytokine signature for the diagnosis of autism spectrum disorder in young Arab children in Qatar
منشور في 2024"…We compared the differences in the levels of these cytokines between the two study groups and then fitted the significantly altered cytokines into a logistic regression model to examine their diagnostic potential for ASD.…"
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Exploring the bearing of liquidity risk in the Middle East and North Africa (MENA) banks
منشور في 2024"…Also, if the bank has no control over the operational expenses, then this will lead to reduce profitability. Liquidity risk, capital adequacy, income diversification, and growth have a positive significant impact on ROE implying that banks with higher growth opportunities, better capital adequacy ratio, more income sources, and liquidity risk will result in higher profitability as explained by the risk-reward theory. …"
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Modelling the utilization rates of pedestrian crosswalks
منشور في 2023"…<p dir="ltr">A zebra crossing is a form of pedestrian crossing provision point on roads that have significant volumes of traffic. It is one of the safety measures employed to reduce avoidable pedestrian-motorist conflicts and accidents on such roads. …"
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Machine Learning Based Photovoltaics (PV) Power Prediction Using Different Environmental Parameters of Qatar
منشور في 2019"…Two different bias calculation techniques were used to evaluate the instances of biased prediction, which can be utilized to reduce bias to improve accuracy. The ANN model outperforms other regression models, such as a linear regression model, M5P decision tree and gaussian process regression (GPR) model. …"