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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Turkronicles: diachronic resources for the fast evolving Turkish language
منشور في 2025"…Specifically, we show that vocabulary divergence increases over time, as expected. …"
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Natural resource dependence and war nexus: new insights
منشور في 2025"…Using a panel probit model, we find that natural resources rents, military expenditures, and the presence of a common law tradition significantly increase the probability of war occurrence. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Security Assessment of Low-Resource Edge Devices for IoT Systems
منشور في 2020احصل على النص الكامل
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The landscape of PreK-12 engineering online resources for teachers
منشور في 2015"…Although professional development offered by universities, school districts, and other educational entities provides the primary source of formal learning tools for teachers, an increasing number of teachers also utilize other informal web-based resources regularly. …"
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The retention of health human resources in primary healthcare centers in Lebanon
منشور في 2012"…Background Critical shortages of health human resources (HHR), associated with high turnover rates, have been a concern in many countries around the globe. …"
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A system dynamics approach to management of water resources in Qatar
منشور في 2024"…Additionally, to aid policymakers in fostering water resource sustainability, groundwater conservation strategies are proposed using the unique scenario design framework by limiting the yield to the safe abstraction level and emphasizing the significance of preserving non-renewable groundwater resources as a “backstop” resource for the country. …"
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Intelligent scaling for 6G IoE services for resource provisioning
منشور في 2021"…Although the demand for change in service from different sectors, the increase in IoE, the limitation of available computing resources of MEC, and intelligent resource solutions are getting much more significant. …"
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Innovation Ecosystem for Resource-Rich Countries: Validation of Entrepreneurship Framework for Qatar as a Case
منشور في 2024"…<p dir="ltr">This study investigated how entrepreneurship can reshape resource-based countries such as Qatar into more diverse, sustainable, and knowledge-driven economies. …"
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LightEnsemble-Guard: An Optimized Ensemble Learning Framework for Securing Resource-Constrained IoT Systems
منشور في 2025"…<p dir="ltr">The rapid proliferation of real-time Internet of Things (IoT) devices has increased the need for efficient and accurate security mechanisms. …"
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Examining the nexus of mineral resources, technology adoption, and economic expansion in advancing sustainable development in OECD economies
منشور في 2024"…The results act as a plea for sustainable regulation of finite resources, increased funding in human capital, and a heightened emphasis on research and innovation. …"
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Application of Tools of Quality Function Deployment and Modified Balanced Scorecard for Optimal Allocation of Pavement Management Resources
منشور في 2020"…Many traditional methods were and are still being used by entities related to pavement management to increase the efficiency of management in decision-making and in coordinating the different activities that have a direct impact on pavement systems. …"