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Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway
منشور في 2022"…Additionally, after β-catenin silencing, OA treatment significantly increased the expression of nuclear transcription factors SREBP-1 and TCF4, whereas Ex-4 significantly decreased this upregulation. Our findings suggest that direct activation of GLP-1R by Ex-4 reduces OA-induced steatosis in HepG2 cells by reducing fatty acid uptake and transport via FABP1 downregulation.…"
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Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes
منشور في 2023"…Three DNAJB3 knockout (KO) lines were generated (KO 30, 44 and 47), using CRISPR-Cas9. Male and female KO and WT mice were fed a HF diet (45% kcal fat) for 16 weeks. …"
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The new accounting standard IFRS 9 and its impact on how banks should provision for credit losses
منشور في 2019"…IFRS9 also can affect deal pricing under the new standard for risky customers may get higher price than normal customers. …"
احصل على النص الكامل
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Genetic engineering to enhance microalgal-based produced water treatment with emphasis on CRISPR/Cas9: A review
منشور في 2023"…Bioremediation using microalgae has received increased interest as a method for produced water treatment for removing not only major contaminants such as nitrogen and phosphorus, but also heavy metals and hydrocarbons. …"
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Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation
منشور في 2021"…Mean ± standard deviation values at the distal femur at 8 weeks were 9.0 ± 2.5 vs. 7.0 ± 1.5 (p = 0.002) and at 52 weeks were 15.8 ± 9.5 vs. 8.5 ± 4.2 (p = 0.002). …"
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Comparing WZB117-liposome Synthesis via Thin-film Hydration and Microfluidic Methods
منشور في 2025احصل على النص الكامل
doctoralThesis -
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Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors
منشور في 2022"…Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, also binds to Sox9 and results in a similar increase in pancreatic development markers. …"
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<i>Asterarcys quadricellulare</i> (Chlorophyceae) protects H9c2 cardiomyoblasts from H<sub>2</sub>O<sub>2</sub>-induced oxidative stress
منشور في 2022"…The protein expression of total caspase-3 was also examined to investigate whether the extract protects H9c2 cardimyoblasts from H2O2-induced apoptosis. …"
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Building A Passive Thermal Management System Using Phase Change Material Embedded In Porous Media
منشور في 2021احصل على النص الكامل
doctoralThesis -
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Enhancing the production of biogas through anaerobic co-digestion of agricultural waste and chemical pre-treatments
منشور في 2020"…Further improvement was achieved via alkalinity treatment with 1.0 g of NaHCO<sub>3</sub>/gVS leading to decrease in lignin, cellulose, and hemicellulose contents of feedstock by 3.5%, 10.5% and 15.9%, respectively, converting them to soluble fractions and improving the CMP by 11.2–29.7% based on substrate quality. …"
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Effect of nickel loading on hydrogen production and chemical oxygen demand (COD) destruction from glucose oxidation and gasification in supercritical water
منشور في 2010"…An increase in MR from 0.55 to 0.8 increased the of carbon dioxide and hydrogen yields from 1.8 to 3.8 mol/mol glucose and from 0.9 to 1.1 mol/mol. …"
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Neonatal autoimmune lymphoproliferative syndrome with a novel pathogenic homozygous FAS variant effectively treated with sirolimus: Case report
منشور في 2023"…<h3>Background</h3><p dir="ltr">Autoimmune lymphoproliferative syndrome (ALPS) is a rare disease characterized by defective FAS signaling, which results in chronic, nonmalignant lymphoproliferation and autoimmunity accompanied by increased numbers of “double-negative” T-cells (DNTs) (T-cell receptor αβ+ CD4−CD8−) and an increased risk of developing malignancies later in life.…"
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Strength and Ductility of Axially Loaded RC Short Columns Confined with CFRP and GFRP Wraps
منشور في 2013احصل على النص الكامل
doctoralThesis