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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Global gene expression profiling of LY411575-treated cells revealed changes in multiple signaling pathways, including focal adhesion, insulin, TGFβ, IL6, and Notch signaling, and decreased the expression of genes associated with functional categories of tissue development. …"
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Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women
منشور في 2021"…In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. …"
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Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women
منشور في 2021"…In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Use of Ultrasound and Ionic Liquids to Enhance the Extractive Desulfurization of Oils
منشور في 2016احصل على النص الكامل
doctoralThesis -
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Numerical Modeling of Sequential Segmentation for Enhancement of Mixing Inside Microchannels
منشور في 2019احصل على النص الكامل
doctoralThesis -
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Brain Connectivity Analysis Under Semantic Vigilance and Enhanced Mental States
منشور في 2019"…BRMUS factors, such as fatigue, depression, and anger, significantly decrease in the enhancement group compared to vigilance group. …"
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Functional Connectivity Analysis under Vigilance Decrement and Enhanced Mental States
منشور في 2020احصل على النص الكامل
doctoralThesis -
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An Improved Genghis Khan Optimizer based on Enhanced Solution Quality Strategy for Global Optimization and Feature Selection Problems
منشور في 2024"…The primary goals of feature selection are to decrease the number of dimensions and enhance classification accuracy in many domains, such as text classification, large-scale data analysis, and pattern recognition. …"
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Energy-Efficient Cell Association and Load Balancing for Low Battery Users in Heterogeneous Cellular Networks
منشور في 2025"…The proposed battery based cell association models perform well in favor of LBUs and clearly show the significance of the proposed approach.…"
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
منشور في 2008"…Development of new, effective therapies for metastatic melanoma that target novel pathways associated with the genesis of metastatic disease is a major unmet clinical need. …"
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conferenceObject -
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Enhancing Thermal Comfort for the Revitalization of Pedestrian-Friendly Shopping Arcades in Dubai, UAE
منشور في 2025"…Using ENVI-met software, simulations are conducted in three stages: urban materials, building facade materials, and vegetation and landscaping, encompassing thirteen different combinations to examine four key aspects: temperature, humidity, wind speed, and PMV value, which significantly affect outdoor thermal comfort. The most favorable cases are selected from each phase, and the final reduction in temperature and PMV values of the optimized case indicates a substantial decrease of 3.76 degrees Celsius in air temperature post-implementation of passive design strategies. …"
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Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis
منشور في 2020"…Remarkably, Africans seem to carry extremely lower frequencies of SARS-CoV-1 susceptibility alleles, reaching to 32-fold decrease compared to other populations.</p><h3>Conclusion</h3><p dir="ltr">Multiple genetic variants, which could potentially modulate SARS-CoV-2 infection, are significantly variable between populations, with the lowest frequency observed among Africans. …"
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Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank
منشور في 2025"…However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R2 = 0.065, ΔF(7, 1724) = 3.34, p = 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. …"
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Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank
منشور في 2024"…However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R<sup>2</sup> = 0.065, ΔF(7, 1724) = 3.34, p= 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. …"