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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Antibiotic use and escherichia coli resistance trends for quinolones and cotrimoxazole in Sweden
منشور في 2002"…Cotrimoxazole resistance has also been increasing significantly in most hospitals, in spite of decreasing sales of cotrimoxazole and trimethoprim. …"
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Predictors of prolonged hospitalization among geriatric trauma patients using the modified 5-Item Frailty index in a Middle Eastern trauma center: an 11-year retrospective study
منشور في 2025"…Severe frailty significantly predicted longer hospitalization (odds ratio 1.83, <i>p</i> = 0.007).…"
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Impact of the positive pressure valve on vascular access device occlusions and bloodstream infections
منشور في 2009"…These types of devices have been shown to significantly decrease VAD occlusion rates by 8.2%, when compared to a standard connector device (Jacobs et al., 2004). …"
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Visitors off the trail: Impacts on the dominant plant, bryophyte and lichen species in alpine heath vegetation in sub-arctic Sweden
منشور في 2021"…The results showed that proximity to the trail did not cause a decrease in the majority of dominant species, with none of the eight most dominant vascular plants showing any significant effects of proximity to the trail. …"
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Clinical and biochemical determinants of length of stay, readmission and recurrence in patients admitted with diabetic ketoacidosis
منشور في 2023"…<h3>Background</h3><p dir="ltr">The increasing prevalence of diabetic ketoacidosis (DKA) related admissions poses a significant burden on the healthcare systems globally. …"
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002)
منشور في 2002"…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …"
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Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats
منشور في 2015"…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …"
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Nutritional Status and Clinical Outcomes of Children with Medical Complexity in the United Arab Emirates: A Retrospective Cross-Sectional Study
منشور في 2025"…Older age at admission was associated with lower WAZ scores (β = -0.053, p < 0.001). Longer hospital length of stay was associated with reduced LAZ scores (β = -0.005, p = 0.006) and increased WLZ scores (β = 0.006, p = 0.035). …"
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The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis
منشور في 2018"…Only Cisplatin treatment caused a significant decrease in body weight and increase in serum ALT. …"
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