Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation حسب Zreik, Tony

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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"

Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis حسب Osama Hussein (21301202)

"…In conclusion, standalone phacoemulsification significantly lowers IOP and reduces the need for glaucoma medications in patients with glaucoma.…"

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells حسب Nihal AlMuraikhi (6002234)

"…Global gene expression profiling of LY411575-treated cells revealed changes in multiple signaling pathways, including focal adhesion, insulin, TGFβ, IL6, and Notch signaling, and decreased the expression of genes associated with functional categories of tissue development. …"

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... حسب Vijay Ganji (8710491)

Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway حسب Olfa Khalifa (10914452)

Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women حسب Vijay, Ganji

"…Serum 25(OH)D appeared to have an inverse ‘U’ association with several adiposity measures. Overall, body adiposity markers were the lowest in the 4th quartile serum 25(OH)D and significantly lower compared to the 1st quartile serum 25(OH)D. …"
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Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women حسب Vijay Ganji (8710491)

"…Serum 25(OH)D appeared to have an inverse ‘U’ association with several adiposity measures. Overall, body adiposity markers were the lowest in the 4th quartile serum 25(OH)D and significantly lower compared to the 1st quartile serum 25(OH)D. …"

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy حسب Jia-Zhen Wu (6844793)

Energy-Efficient Cell Association and Load Balancing for Low Battery Users in Heterogeneous Cellular Networks حسب Abdul Qadeer Khan (22502168)

"…The proposed battery based cell association models perform well in favor of LBUs and clearly show the significance of the proposed approach.…"

Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis حسب Maria K. Smatti (4675852)

"…Analysis of Qatari genomes revealed significantly lower AF of risk variants linked to SARS-CoV-1 severity (CCL2, MBL, CCL5, AHSG, and IL4) compared to that of 1000Genome and/or the EAS population (up to 25-fold change). …"

Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank حسب Al-Hamdani, Mohammed

"…However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R2 = 0.065, ΔF(7, 1724) = 3.34, p = 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. …"
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Associations between Bone Mineral Density and WOMAC Scores in Healthy Individuals: Insights from the Qatar Biobank حسب Mohammed Al-Hamdani (16962702)

"…However, BMD measures significantly contributed to predicting stiffness after controlling for sociodemographic variables (R² = 0.065, ΔF(7, 1724) = 3.34, p= 0.002), with a higher total body BMD associated with increased stiffness and a higher trunk BMD associated with decreased stiffness. …"

Rhegmatogenous retinal detachments associated to Stickler syndrome in a tertiary eye care center in Saudi Arabia حسب Alshahrani, Saeed T.

"…Visual acuity improved in 54% of eyes and decreased in 5%. Statistically significant associations were present for eyes with final visual acuity ≥20/200, and total retinal detachment (P<0.001); preoperative cataract (P=0.023); and proliferative vitreoretinopathy (P<0.001). …"
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Association Between Three-Months Vitamin D Supplementation and Depressive Symptomatology incidence among Saudi Arabian Adults حسب Khaddaj, Rashel

"…When vitamin D was considered as continuous variable, each unit increase in vitamin D levels was associated with a lower depression prevalence (OR=0.87; 95% CI:0.79-0.95, p=0.005) and when compared to those insufficient, those deficient were 4 times more likely to suffer from depression (OR=4.47, 95% CI:1.39-14.38,p=0.012) Nevertheless, these significant results were lost with further adjustment for BMI, MeDi adherence and physical activity: continuous vitamin D: OR=0.90; 95% CI: 0.81-1.01, p=0.08, deficient versus insufficient:OR=2.18; 95% CI: 0.56-8.47,p=0.259). …"
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Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications حسب Fang Yu (156838)

"…<p>Loss of function mutations in store-operated Ca²⁺ entry (SOCE) are associated with severe paediatric disorders in humans, including combined immunodeficiency, anaemia, thrombocytopenia, anhidrosis and muscle hypotonia. …"

Exploring the dynamics of algae-associated microbiome during the scale-up process of Tetraselmis sp. microalgae: A metagenomics approach حسب Hoda, Hosseini

"…Microbial profiling of each successive stage revealed lower abundance of eukaryotic organisms, whereas bacterial abundance increased notably resulting in a significant decrease in Tetraselmis sp. abundance. …"
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Exploring the dynamics of algae-associated microbiome during the scale-up process of Tetraselmis sp. microalgae: A metagenomics approach حسب Hoda Hosseini (16932462)

"…Microbial profiling of each successive stage revealed lower abundance of eukaryotic organisms, whereas bacterial abundance increased notably resulting in a significant decrease in Tetraselmis sp. abundance. …"

Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation حسب Mai S., El-Shoukrofy

"…As well, the expression levels of 20-HETE, Il-1β and TNF-α were decreased in LPS-challenged RAW264.7 macrophages upon treatment with compound 2a. …"
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PGAP3 Associated with Hyperphosphatasia with Mental Retardation Plays a Novel Role in Brain Morphogenesis and Neuronal Wiring at Early Development حسب Sahar I. Da’as (9631717)

"…Altogether, we report a novel pathogenic PGAP3 variant associated with unique phenotypic hallmarks, which may be related to the gene’s novel role in brain morphogenesis and neuronal wiring.…"