Conserved genes regulating human sex differentiation, gametogenesis and fertilization حسب Khalid A. Fakhro (3158862)

"…The rapid and continuous screening and identification of putative genetic defects coupled with an efficient functional characterization in animal models can reveal novel mechanisms of gene function in human reproductive tissues.…"

Seizure-like behavior and hyperactivity in <i>napb</i> knockout zebrafish as a model for autism and epilepsy حسب Kyung Chul Shin (13913556)

"…Notably, Qatari monozygotic triplets with loss of function mutations in <i>NAPB</i> exhibit early onset epileptic encephalopathy and varying degrees of autism. …"

Transcriptome profiling and network enrichment analyses identify subtype-specific therapeutic gene targets for breast cancer and their microRNA regulatory networks حسب Ramesh Elango (7542068)

"…Integration of our transcriptomic data with CRISPR-Cas9 functional screen data and the OncoKB database identified numerous dependencies and therapeutic vulnerabilities in each BC molecular subtype, while CDC123 was functionally validated as potential therapeutic target for TNBC. …"

Therapeutic targeting of the TPX2/TTK network in colorectal cancer حسب Hibah Shaath (5599658)

"…Integration of TPX₂/TTK enriched network with CRISPR-Cas9 functional screen data identified numerous novel dependencies for CRC. …"

Single-Cell Transcriptome Analysis Revealed Heterogeneity and Identified Novel Therapeutic Targets for Breast Cancer Subtypes حسب Radhakrishnan Vishnubalaji (3563306)

"…Integration of single-cell transcriptomic with CRISPR-Cas9 functional screen data identified 13 potential therapeutic targets for ER⁺, 44 potential therapeutic targets for HER2⁺, and 29 potential therapeutic targets for TNBC. …"