Integrated Transcriptome and Pathway Analyses Revealed Multiple Activated Pathways in Breast Cancer حسب Radhakrishnan Vishnubalaji (3563306)

Integrated whole transcriptome and small RNA analysis revealed multiple regulatory networks in colorectal cancer حسب Hibah Shaath (5599658)

Transcriptomic profiling and bioinformatics-driven statistical prioritization of CRC biomarkers: A step toward precision oncology حسب Rawdhah M. Saleh (21436001)

الموضوعات:

Integrated transcriptional‐phenotypic analysis captures systemic immunomodulation following antiangiogenic therapy in renal cell carcinoma patients حسب Darawan Rinchai (742366)

An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos حسب Wenqing Jean Lee (18891991)

"…By combining cell type-specific transcriptome analysis and in vivo ChIP-Seq of the Sox trio using mouse embryos, we provide evidence for the direct control of Sox5 and Sox6 by the transcriptional trio in the murine model and by Morpholino knockdown in zebrafish and demonstrate the novel role of Tgfb2, Fbxl18, and Tle3 in formation of Sox5, Sox6, and Sox9 dependent tissues. …"

Single-Cell Transcriptome Analysis Revealed Heterogeneity and Identified Novel Therapeutic Targets for Breast Cancer Subtypes حسب Radhakrishnan Vishnubalaji (3563306)

"…Integration of single-cell transcriptomic with CRISPR-Cas9 functional screen data identified 13 potential therapeutic targets for ER⁺, 44 potential therapeutic targets for HER2⁺, and 29 potential therapeutic targets for TNBC. …"

Technical assessment of different extraction methods and transcriptome profiling of RNA isolated from small volumes of blood حسب Mahesh Kumar Reddy Kalikiri (17886695)

الموضوعات:

A curated transcriptome dataset collection to investigate inborn errors of immunity حسب Salim Bougarn (413372)

"…Here we have compiled a manually curated collection of public transcriptome datasets mainly obtained from human whole blood, peripheral blood mononuclear cells (PBMCs) or fibroblasts of patients with PIDs and of control subjects for subsequent meta-analysis, query and interpretation. …"

Transcriptome profiling and network enrichment analyses identify subtype-specific therapeutic gene targets for breast cancer and their microRNA regulatory networks حسب Ramesh Elango (7542068)

"…Our data provides comprehensive transcriptomic profiling and unraveled the miRNA-mRNA regulatory networks in BC patients from the region and identified novel actionable gene targets, employing integrated approach. …"

A data browsing application for accessing gene and module-level blood transcriptome profiles of healthy pregnant women from high- and low-resource settings حسب Darawan Rinchai (742366)

"…We deployed a web application, accessible at https://thejacksonlaboratory.shinyapps.io/BloodGen3_Pregnancy/which displays the module-level analysis results from both original and public pregnancy blood transcriptome datasets. …"

The multiomics analyses of cancer stem cells isolated from solid tumors can provide insight for their immunological characterization. حسب Neha Gopinath (15431052)

"…</p> <p>Objective: The aim of this study is to identify the molecular mechanisms regulating the immunological properties of cancer stem cells (CSCs) isolated from colorectal cancer (CRC) and breast cancer (BC) using integrative approaches including flow cytometry, miRNAs and RNA seq-based transcriptomic profile and in vitro functional assays.…"

A multi-omics approach reveals dysregulated TNF-related signaling pathways in circulating NK and T cell subsets of young children with autism حسب Wared Nour-Eldine (13904298)

"…Using a multimodal approach, we integrated transcriptomic, proteomic, and single-cell RNA-seq data analyses from this cohort. …"

Integrating Genome Sequencing and Untargeted Metabolomics in Monozygotic Twins with a Rare Complex Neurological Disorder حسب Rulan Shaath (17112852)

"…<p dir="ltr">Multi-omics approaches, which integrate genomics, transcriptomics, proteomics, and metabolomics, have emerged as powerful tools in the diagnosis of rare diseases. …"

Immunoprofile of childhood diabetes حسب Meritxell Espino-Guarch (15430868)

"…A comparative analysis of the transcriptome of the two major subtypes of CD4+ T cells, regulatory-T cells (Treg) and conventional T cells (Tcon) was conducted and compared with the plasma metabolome of 14 Control, 19 Obese, 17 Pre-diab, 16 T2D, and 20 T1D cases. …"

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes حسب Noura Aldous (15429873)

"…RT-qPCR was performed for validating selected DEGs and miRNAs. </p> <p>Results: Transcriptome analysis on FOXA2–/–PPs compared to WT-PPs revealed 1628 down-regulated (Log2 FC < −1.0, p < 0.05) and 769 up-regulated (Log2 FC > 1.0, p < 0.05) DEGs. …"

miRCOVID-19: Potential Targets of Human miRNAs in SARS-CoV-2 for RNA-Based Drug Discovery حسب Tanvir Alam (638619)

"…<div><p>Sense-antisense interactions of long and short RNAs in human cells are integral to post-transcriptional gene regulation, in particular that of mRNAs by microRNAs. …"