DNA Methylation Biomarkers in Aging and Age-Related Diseases by Yasmeen Salameh (8552571)

Tolfenamic Acid Derivatives: A New Class of Transcriptional Modulators with Potential Therapeutic Applications for Alzheimer’s Disease and Related Disorders by Jaunetta Hill (18255631)

“…<p dir="ltr">The field of Alzheimer’s disease (AD) has witnessed recent breakthroughs in the development of disease-modifying biologics and diagnostic markers. …”

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation by Larissa Haertle (3864310)

“…Performing a targeted association analysis for the significant T21-associated CpG sites in the AgeCoDe cohort, we found that 9 showed significant methylation differences related to AD dementia, including one in the ADAM10 gene. …”

A genome-wide DNA methylation signature for SETD1B-related syndrome by I. M. Krzyzewska (18614968)

“…Here, we identify a specific hypermethylation signature associated with loss of function mutations in theSETD1Bgene which may be used as an epigenetic marker supporting the diagnosis of syndromicSETD1B-related diseases. …”

Bi-allelic truncating variants in <i>CASP2</i> underlie a neurodevelopmental disorder with lissencephaly by Eyyup Uctepe (19342522)

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... by Marissa B Reitsma (8674341)

“…</p><p><br></p><h3>Findings</h3><p dir="ltr">Globally in 2019, 1·14 billion (95% uncertainty interval 1·13–1·16) individuals were current smokers, who consumed 7·41 trillion (7·11–7·74) cigarette-equivalents of tobacco in 2019. …”

Comparative study of the parameters affecting the performance of microchannels' heat exchangers: Latest advances review by Muhammad Asim (2235472)

“…When the fluid is added with nanoparticles, like, Al2O3 and copper oxide (CuO) with different volumetric fractions (φ) of 0%, 0.5%, 1%, 1.5%, and 2%, the performance of the microchannel rises with rising the Reynolds number but conversely when the fluid is used in pure form the performance decreases with the rising value of Reynolds number. …”

Burden of Transport-Related Injuries in the Eastern Mediterranean Region: A Systematic Analysis for the Global Burden of Disease Study 2017 by Saeid Safiri (3713035)

The solution of a recursive sequence arising from a combinatorial problem in botanical epidemiology by Al-Sharawi, Ziyad

“…One of the central problems in botanical epidemiology is whether disease spreads within crops in a regular pattern or follows a random process. …”
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Expression of CD91 in extracellular vesicles: A potential biomarker for the diagnosis of non-small cell lung cancer by Shayista Akbar (14442117)

Thalidomide-Revisited: Are COVID-19 Patients Going to Be the Latest Victims of Yet Another Theoretical Drug-Repurposing? by Athar Khalil (5906330)

Changes and trends of pre-hospital emergency disease spectrum in Beijing in the past decade (from 2003 to 2012) by Tianbing Wang (514759)

“…The top five call demands based on the rank of proportion were trauma related demands(25.4%, including falls（5.0%）, traffic/ transportation incidents(7.2%) and traumatic injuries(13.1%)), sick person(17.7%), heart problems(11.4%), unconscious/fainting（10.0%） and breathing problems（8.1%）Also, they were the top five fastest growing call demands.…”

Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease by Hidetomo Murakami (6105284)

“…<h3>Background and aim</h3><p dir="ltr">Toxic oligomeric α-synuclein (αS; O-αS) has been suggested to play a central role in the pathogenesis of Lewy body diseases such as Parkinson’s disease (PD). Cerebrospinal fluid (CSF) levels of αS, O-αS, total and phosphorylated tau, and amyloid β 1–42 (Aβ1–42) are thought to reflect the pathophysiology or clinical symptoms in PD. …”

Pregnancy-related issues in women with multiple sclerosis: an evidence-based review with practical recommendations by Beatriz Canibaño (18102676)

“…Pregnancies in MS are not <i>per se</i> high risk pregnancies, and MS does not influence the mode of delivery or anesthesia unless in the presence of significant disability. …”

Cross-sectional proteomic expression in Parkinson's disease-related proteins in drug-naïve patients vs healthy controls with longitudinal clinical follow-up by Ilham Yahya Abdi (17870462)

“…In conclusion, with the use of advance multiplex proteomic technology, a blood-based protein signature profile was identified from serum samples of a well-characterized PD cohort capable of potentially differentiating PD from HC and predicting clinical disease progression of related motor and non-motor PD symptoms. …”

Founder Mutation in N Terminus of Cardiac Troponin I Causes Malignant Hypertrophic Cardiomyopathy by Akl C. Fahed (11514346)

“…Using cascade screening, we studied the clinical phenotype of 57 individuals from the 5 families with <i>TNNI3</i> p.Arg21Cys-related cardiomyopathy. …”

Joint analysis of diet quality, inflammatory potential of diet and ultra-processed food exposure in relation to chronic respiratory diseases and lung cancer mortality by Tefera Chane, Mekonnen

“…ObjectiveExamined the combined effects of ultra-processed food (UPF), Dietary Inflammatory Index (DII), Healthy Eating Index-2015 (HEI-2015), and Dietary Antioxidant Index (DAI) on mortality from chronic respiratory diseases (CRDs), chronic obstructive pulmonary disease (COPD), and lung cancer. …”
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Comparative Transcriptome Analysis Reveals That Exendin-4 Improves Steatosis in HepG2 Cells by Modulating Signaling Pathways Related to Lipid Metabolism by Khaoula Errafii (10914446)

Screening for Novel Inhibitors of Amyloid Beta Aggregation and Toxicity as Potential Drugs for Alzheimer’s Disease by Sanaa Sharari (12561952)

“…However, one of the promising approaches for therapeutic intervention is to use inhibitors for blocking the Aβ peptide aggregation process. …”

Spontaneous Bacterial Peritonitis Beyond the Usual Suspects: Case Series of <i>Salmonella</i> and <i>Brucella</i> With Comprehensive Literature Review by Hussam Almasri (9376817)

“…The first case involved a 58‐year‐old female with a history of hepatitis C‐related chronic liver disease and cryoglobulinemic vasculitis, who presented with SBP and hepatorenal syndrome‐associated acute kidney injury. …”