Search alternatives:
a decrease » _ decreased (Expand Search), _ decreases (Expand Search)
c decrease » _ decreased (Expand Search), _ decreases (Expand Search)
_ we » _ web (Expand Search), _ e (Expand Search), _ fe (Expand Search)
5 c » 45 c (Expand Search)
a decrease » _ decreased (Expand Search), _ decreases (Expand Search)
c decrease » _ decreased (Expand Search), _ decreases (Expand Search)
_ we » _ web (Expand Search), _ e (Expand Search), _ fe (Expand Search)
5 c » 45 c (Expand Search)
-
1
-
2
Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Published 2019“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
Get full text
Get full text
-
3
L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats .
Published 2020“…Conflicting evidence for this may result from some studies assuming that all L4-fibers are undamaged. Here, we recorded somatic action potentials (APs) intracellularly from C- and A-fiber L4/L5 DRG neurons to examine our hypothesis that L5-SNA would induce distinct electrophysiological changes in the two populations of DRG neurons. …”
Get full text
Get full text
-
4
Ferroelectric Properties and Electrocaloric Effect in Dy2O3 Substitution on Lead-Free (Na0.5 Bi0.5)0.94 Ba0.06TiO3 Ceramic
Published 2023“…Using the direct EC measurement, the ceramic corresponding to y = 0.02 exhibited a significant EC response, where ΔT = 1.2 K under 5 kV/mm. …”
Get full text
-
5
-
6
-
7
-
8
Cutaneous Aβ-Non-nociceptive, but Not C-Nociceptive, Dorsal Root Ganglion Neurons Exhibit Spontaneous Activity in the Streptozotocin Rat Model of Painful Diabetic Neuropathy .
Published 2020“…Compared with control, we found in STZ-rats with established pain hypersensitivity (5 weeks post-STZ) several significant changes including: (a) A 23% increase in the incidence of spontaneous activity (SA) in Aβ-LTMs (but not C-mechanosensitive nociceptors) that may cause dysesthesias/paresthesia suffered by DPNP patients, (b) membrane hyperpolarization and a ∼85% reduction in SA rate in Aβ-LTMs by K7 channel activation with retigabine (6 mg/kg, i.v.) suggesting that K7/M channels may be involved in mechanisms of SA generation in Aβ-LTMs, (c) decreases in AP duration and in duration and amplitude of afterhyperpolarization (AHP) in C-and/or Aβ-nociceptors. …”
Get full text
Get full text
-
9
Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart
Published 2014“…Our results showed that mercury treatment caused a significant induction of the cardiac hypertrophy markers, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP); in addition to Cyp1a1, Cyp1b1, Cyp2b9, Cyp2b10, Cyp2b19, Cyp2c29, Cyp2c38, Cyp4a10, Cyp4a12, Cyp4a14, Cyp4f13, Cyp4f15, Cyp4f16 and Cyp4f18 gene expression. …”
Get full text
Get full text
-
10
Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model
Published 2020“…MYBPC3 variants genotype–phenotype associations remain poorly understood. We investigated the impact of two novel human MYBPC3 splice-site variants: V1: c.654+2_654+4dupTGG targeting exon 5 using morpholino MOe5i5; and V2: c.772+1G'A targeting exon 6 using MOe6i6; located within C1 domain of cMyBP-C protein, known to be critical in regulating sarcomere structure and contractility. …”
Get full text
Get full text
Get full text
-
11
-
12
-
13
-
14
-
15
-
16
Implementing and Analyzing a Recursive Technique for Building Path Oblivious RAM
Published 2018“…We employ a recursive generalized version of this approach. …”
Get full text
Get full text
-
17
Qatar Culture Collection of Microalgae: A Sustainable Source for Biodiesel Production and Omega Fatty Acid Compounds
Published 2016“…In addition, we observed the presence of the omega-3 and 9 long-chain polyunsaturated fatty acids (LC-PUFAs), such as eicosapentaenoic (EPA, 20:5 n-3), docosahexaenoic (DHA, 22:6 n-3) and Nervonic Acid (C24:1 n-9) acids, which have a high commercial value and are known for their beneficial effects on human health…”
Get full text
Get full text
-
18
Sorption of benzene and naphthalene on (semi)-arid coastal soil as a function of salinity and temperature
Published 2018“…The sorption of naphthalene was not affected by the change in salinity but increased by 18% when the temperature decreased from 35 to 5 �C. A sorption kinetic model was also applied to define the sorption behavior of benzene and naphthalene for the coastal soil collected in Qatar and the best fits were achieved with the Langmuir sorption isotherm.…”
Get full text
Get full text
-
19
Impact of the COVID-19 pandemic on sexually transmitted infection testing and diagnosis in Lebanon: A retrospective chart review
Published 2024“…MethodsThis was a retrospective analysis of the clinic's database, including data on voluntary counseling and testing (VCT) for HIV, syphilis, hepatitis B virus (HBV), and hepatitis C virus (HCV). …”
Get full text
Get full text
Get full text
article -
20