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Decreased phosphodiesterase activities in cardiac hypertrophy
Published 2007“…The efficacy of isoprenaline (Iso) to increase ICNG was decreased in H myocytes vs. S, whereas the response to forskolin (100 μM) was unchanged. …”
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Decreased Expression and Activity of cAMP Phosphodiesterases in Cardiac Hypertrophy and Its Impact on β-Adrenergic cAMP Signals
Published 2009“…The inotropic response to maximal β-adrenergic stimulation was reduced by ≈54% in isolated hypertrophied hearts, along with a ≈32% decrease in subsarcolemmal cAMP levels in hypertrophied myocytes. …”
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A 28 nm CMOS 10 bit 100 MS/s Asynchronous SAR ADC with Low-Power Switching Procedure and Timing-Protection Scheme
Published 2021“…<div><p>This paper presents a 10 bit 100 MS/s asynchronous successive approximation register (SAR) analog-to-digital converter (ADC) without calibration for industrial control system (ICS) applications. …”
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Subsarcolemmal cAMP signals monitored by cyclic nucleotide gated channels in hypertrophied cardiac myocytes
Published 2005“…Cumulative concentrationresponse curve to the non-selective E-adrenergic agonist isoprenaline (Iso) indicated a 33% decrease of the maximal cAMP accumulation produced by Iso while the effect of the hydrosoluble forskolin analog, L-858051 at a saturating concentration (100 µM) was unchanged between the two groups. …”
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Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways
Published 2017“…HC showed a dose-dependent decrease in cell survival with an IC50 of 18 and 14.5 μg/ml after 24 and 48 h respectively. …”
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
Published 2017“…Results β-2-himachalen-6-ol showed a dose-dependent decrease in cell survival with an IC50 and IC90 of 8 and 30 μg/ml, respectively. …”
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Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines
Published 2022“…Monotherapy with CBD demonstrated a dose-dependent tumor growth inhibition at 72h, with the IC50 being 12.5 μg/ml for OVCAR-3 cell line and 12.3 μg/ml for SK-OV-3 cell line. …”
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The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis
Published 2018“…Papilloma yield, volume, histology, and mice weight and liver function were assessed. HC treatment decreased significantly cell survival (IC50 = 7 and IC90 = 40 μg/ml) and increased significantly cells undergoing late apoptosis and necrosis. …”
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Simulation of the size-composition distribution of atmospheric nanoparticles over Europe
Published 2018“…The ground level concentrations of particles with a diameter larger than 100 nm (N100) were reproduced with a daily normalized mean error of 40 % and a daily normalized mean bias of −20 %. …”
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Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer
Published 2017“…The cytotoxic effect of fractions (10, 25, 50 and 100 μg/mL) was tested on human epidermal keratinocytes (non-tumorigenic HaCaT cells and tumorigenic HaCaT-ras variants) using WST a ssay. …”
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Preparation of albumin-targeted liposomes and the study of their release characteristics using ultrasound
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Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model
Published 2019“…For the first time, we investigate the potential organ-specific (cardiac, hepatic, and neuromuscular) toxicity of ChNPs (size 100–150 nm) using the zebrafish embryo model. Our data highlight the absence of both acute and teratogenic toxic effects of ChNPs (~100% survival rate) even at the higher concentration employed (200 mg/L). …”
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Disrupted harvests: how Ukraine – Russia war influences global food systems – a systematic review
Published 2024“…Utilizing a rigourous methodology, we screened 236 articles from the Web of Science database as of March 2023, narrowing the corpus to 62 significant publications that meet comprehensive eligibility criteria. …”
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Effect of Girder Damage on the Structural Behavior of Slab-on-Girder Bridges
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doctoralThesis -
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Occurrence and removal characteristics of phthalate esters from bottled drinking water using silver modified roasted date pits
Published 2022“…The removal percentage was increased from 90 to 99% by increasing the temperature from 30 to 50 °C and then decreased to 92.3% at 60 °C.</p> <h2>Conclusion</h2> <p>RODP was successfully used as an effective adsorbent for phthalate esters removal from drinking water. …”
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Social Network Analysis for Precise Friend Suggestion for Twitter by Associating Multiple Networks Using ML
Published 2022“…This approach is by and large used to decrease the dimensionality of the information alongside its feature space. …”