DNA Methylation Biomarkers in Aging and Age-Related Diseases by Yasmeen Salameh (8552571)

“…<p dir="ltr">Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease. It is currently well established that DNA methylation biomarkers can determine biological age of any tissue across the entire human lifespan, even during development. …”

Breast Disease-Related Educational Outcomes at the University of Florida by Lind, D. Scott

“…Limiting breast surgery to a single service does not appear to improve resident accumulation and retention of breast disease-related knowledge. …”
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Unusual Presentation of an Orphan Syndrome Masquerading as Castleman Disease in a Young Adult: Diagnostic Challenges and Clinical Implications: A Case Report by Mohamed Gaafar Mohamedali (17945609)

“…<p dir="ltr">IgG4‐related disease (IgG4‐RD) is a rare and diagnostically challenging fibroinflammatory condition characterized by diverse clinical presentations. …”

Potential efficacy of crizanlizumab in treating priapism in sickle cell disease: A case report by Mohammed Abdulgayoom (14777791)

“…<h3>Key Clinical Message</h3><p dir="ltr">This report documents the treatment of a 41‐year‐old male with sickle cell disease (SCD) and repeated stuttering priapism using crizanlizumab, which alleviated the priapism but induced a significant vaso‐occlusive crisis during the second infusion. …”

The solution of a recursive sequence arising from a combinatorial problem in botanical epidemiology by Al-Sharawi, Ziyad

“…One of the central problems in botanical epidemiology is whether disease spreads within crops in a regular pattern or follows a random process. …”
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Atypical IgG4‐related disease limited to the sino‐nasal cavity: A case report by Ahmed Shaikh (14777452)

“…<p></p><div> <p>Given the overlapping clinical features of sino-nasal immunoglobulin 4-related disease (IgG4-RD) to rhinitis or rhinosinusitis, this paper aims to delineate this rare, isolated manifestation significant to physicians for their daily practice and researchers contributing to this field.…”

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation by Larissa Haertle (3864310)

“…Furthermore, T21 patients have a high risk of developing Alzheimer’s disease (AD) early in life, characterized by the presence of senile plaques of amyloid protein and neurofibrillary tangles, leading to neuronal loss and cognitive decline. …”

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... by Marissa B Reitsma (8674341)

“…<h3>Background</h3><p dir="ltr">Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally.…”

Burden of Transport-Related Injuries in the Eastern Mediterranean Region: A Systematic Analysis for the Global Burden of Disease Study 2017 by Saeid Safiri (3713035)

Tolfenamic Acid Derivatives: A New Class of Transcriptional Modulators with Potential Therapeutic Applications for Alzheimer’s Disease and Related Disorders by Jaunetta Hill (18255631)

“…<p dir="ltr">The field of Alzheimer’s disease (AD) has witnessed recent breakthroughs in the development of disease-modifying biologics and diagnostic markers. …”

Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea by Ioannis N. Petropoulos (8748726)

“…We now seek to demonstrate the utility of CCM to assess neurodegeneration in relation to disease onset and progression, subtypes, and treatment efficacy in patients with rosacea.…”

Rising mortality related to cardiovascular disease and prostate cancer amongst older men across the United States by Abdul Ahad (545575)

Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits by A. H. B. Chin (17787767)

“…<p dir="ltr">In recent years, the genetic testing and selection of IVF embryos, known as preimplantation genetic testing (PGT), has gained much traction in clinical assisted reproduction for preventing transmission of genetic defects. However, a more recent ethically and morally controversial development in PGT is its possible use in selecting IVF embryos for optimal intelligence quotient (IQ) and other non–disease-related socially desirable traits, such as tallness, fair complexion, athletic ability, and eye and hair colour, based on polygenic risk scores (PRS), in what is referred to as PGT-P. …”

Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia by Abu Saleh Md Moin (6189512)

“…<p dir="ltr">We have reported that hypoglycemia was associated with changes in Alzheimer’s disease (AD)-related proteins in accord with the direct link of cognitive dysfunction to hypoglycemia. …”

Changes and trends of pre-hospital emergency disease spectrum in Beijing in the past decade (from 2003 to 2012) by Tianbing Wang (514759)

“…<h3 dir="ltr">Backgrounds</h3><p dir="ltr">Pre-hospital emergency call is a crucial index to indicate emergency disease spectrum. …”

Pregnancy-related issues in women with multiple sclerosis: an evidence-based review with practical recommendations by Beatriz Canibaño (18102676)

“…</p><h3>Results</h3><p dir="ltr">MS has no effect on fertility, pregnancy or fetal outcomes, and pregnancies do not affect the long-term disease course and accumulation of disability. There is a potential risk for relapse after use of gonadotropin-releasing hormone agonists during assisted reproduction techniques. …”

Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage by Florence Hariton (18629764)

“…<div><p>Increased cell senescence contributes to the pathogenesis of aging and aging-related disease. Senescence of human fibroblasts in vitro may be delayed by culture in low glucose concentration. …”

Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 by Christopher J L Murray (13580635)

“…The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. …”

Cross-sectional proteomic expression in Parkinson's disease-related proteins in drug-naïve patients vs healthy controls with longitudinal clinical follow-up by Ilham Yahya Abdi (17870462)

“…In conclusion, with the use of advance multiplex proteomic technology, a blood-based protein signature profile was identified from serum samples of a well-characterized PD cohort capable of potentially differentiating PD from HC and predicting clinical disease progression of related motor and non-motor PD symptoms. …”

Diabetes-related cardiovascular and economic burden in patients hospitalized for heart failure in the US: a recent temporal trend analysis from the National Inpatient Sample by Menatalla Mekhaimar (14103708)