In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway by Kuttikrishnan, Shilpa

“…FOXM1 and BUB1B expression exhibited a dose-dependent reduction in NSP-B-treated CTCL cells.FOXM1 silencing decreased cell viability and increased apoptosis via BUB1B downregulation. …”
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Thiostrepton inhibits growth and induces apoptosis by targeting FoxM1/SKP2/MTH1 axis in B-precursor acute lymphoblastic leukemia cells by Kuttikrishnan, Shilpa

“…In the current study, we showed that the downregulation of FoxM1 by its inhibitor thiostrepton inhibited cell viability and induced caspase-dependent apoptosis in a panel of B-pre-ALL cell lines. Thiostrepton led downregulation of FoxM1 accompanied by decreased expression of Aurora kinase A, B, matrix metalloproteinases, and oncogene SKP2 as well as MTH1. …”
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Novel Isosteviol Derivatives Induced Apoptosis In Human Lung Cancer by Malki, Ahmed

“…Our data showed that novel MOM-ether analogs of isosteviol 8c and 9d decreased cell proliferation and induced apoptosis in H1299 lung cancer cells more than p53 stably transfected H1299 cells. …”
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Production Of Size-selected Copper Nanoclusters For Petroleum Refinery Applications by Ayesh, Ahmad

“…Atomic nanoclusters exhibit large surface to volume ratio which enhances their ability to interact with external materials, thus, they can be utilized efficiently for catalysts and gas sensing applications. …”
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The mitochondria: A target of polyphenols in the treatment of diabetic cardiomyopathy by Bhagani, Humna

“…Bcl-2 acts to attenuate apoptosis, UCP2 decreases oxidative stress, SIRT-1 increases mitochondrial biogenesis and decreases oxidative stress, AMPK increases autophagy, and JNK1 decreases apoptosis and increases autophagy. …”
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The Interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets by Cenciarelli, Carlo

“…Herein, we report that exposure to a Stat3/5 inhibitor, induced apoptosis either in shHes1-CSC or control cells. Taken together, Hes1 seems to be a favorable target but not sufficient itself to target GBM efficaciously, therefore a possible pharmacological intervention should provide for the use of anti-Stat3/5 drugs either alone or in combination regimen.…”
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Beta-caryophyllene exhibits anti-proliferative effects through apoptosis induction and cell cycle modulation in multiple myeloma cells by Mannino, Federica

“…BCP treatment reduced cell proliferation through CB2R stimulation; notably, BCP considerably increased the pro-apoptotic protein Bax and decreased the anti-apoptotic molecule Bcl-2. Furthermore, an increase in caspase 3 protein levels was detected following BCP incubation, thus demonstrating its anti-proliferative effect through apoptosis activation. …”
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BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells. by Alhoshani, Ali

“…The present study explores the molecular mechanisms of VCX-mediated inhibitory effects on the growth and proliferation of TNBC MDA-MB-231 cells through the induction of apoptosis, cell cycle arrest, and autophagy. The study also explores the role of BCL-2 as a novel targeted therapy for breast cancer.…”
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Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic... by Alhujaily, Muhanad

“…MG activated the intrinsic pathway of apoptosis, with decrease of mitochondrial and spliceosomal proteins. …”
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MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS by Hourani, Shireen Bayan

“…CSCs induce chemoresistance through downregulating genes responsible for apoptosis, autophagy, and tumor suppression. Targeting dysregulated CSCs pathways could be a potential therapy for overcoming chemoresistance.…”
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The Impact of Pamam Dendrimers on Her2-Positive Breast Cancer and the Early Stages of Embryogenesis by Kheraldine, Hadeel

“…The anti-cancer effects of PAMAMs including cell viability, colony formation, and apoptosis were studied in HER2-positive breast cancer cells; SK-BR3 and ZR-75. …”
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AMPK Activation Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro by Allouch, Soumaya

“…Intriguingly, the pro-apoptotic protein CHOP was induced following treatment with metformin; nonetheless, the expression of apoptotic markers caspase-12 and caspase-3 was reduced by 80% and 70% respectively, indicating that metformin protected the cells against albumin-induced apoptosis. Conclusion: Albumin treatment induces ER stress, and activates AKT, EMT and apoptosis, with concomitant decreases in autophagy and inactivation of AMPK in renal tubular cells. …”
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Anti-Neoplastic Effects of Annonacin against Renal Cell Carcinoma by Munusamy, Shankar

“…In addition, a dose-dependent decrease in the phosphorylation of p70S6 kinase (a downstream target of mTOR) was observed with annonacin treatment at both 24 and 48 h end-points. …”
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Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells by Abdulrahman, Nabeel

“…Conclusions: These findings suggest that combining cisplatin with agents that target the RSK mediated cell survival pathway, may potentiate the cisplatin effect in lung adenocarcinoma.…”
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PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells by Banasavadi-Siddegowda, Y K

“…This is the first study to identify PTEN as a potential downstream target of PRMT5 and PRMT5 is vital to support both mature and immature GBM tumour cell populations.…”
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Improvement of ternary recycled polymer blend reinforced with date palm fibre by Khanam, P. Noorunnisa

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Clinical significance of P-class pumps in cancer (Review) by Themistocleous, Sophia C.

“…For example, the NKA β2 subunit can be downregulated by gemcitabine, resulting in increased apoptosis of cancer cells. The sarcoendoplasmic reticulum calcium ATPase can be inhibited by thapsigargin resulting in decreased prostate tumor volume, whereas the HKA α subunit can be affected by proton pump inhibitors in gastric cancer cell lines, inducing apoptosis. …”
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Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties by Mesmar, Joelle

“…Triple-negative BC (TNBC) is the most aggressive BC, being resistant to hormonal and targeted therapies. Hypothesis/Purpose: The medicinal plant Origanum syriacum L. is a shrubby plant rich in bioactive compounds and widely used in traditional medicine to treat various diseases. …”
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The role of NF-κB and AhR transcription factors in lead-induced lung toxicity in human lung cancer A549 cells. by Attafi, Ibraheem M

“…Pb treatment induced oxidative stress by a) increasing the formation of reactive oxygen species and b) decreasing GSTA1 mRNA levels. The toxic effects of Pb on the lung was associated with significant increases in NF-κB and AhR levels which was accompanied with increases in downstream targets genes, iNOS and CYP1A1, respectively. …”
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Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice by Ayman, Alzu'bi

“…This study provided new targets for possible medical interventions to improve the treatment guidelines for SCs addiction.…”
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