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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
Published 2025“…Further, mutational analysis revealed a requirement for both cleavage sites to be intact for increased cleavage rate. Importantly, the inclusion of an Mpro-binding, but non-inhibiting, NB2E3 nanobody at the N-terminal further increased the cleavage rate of the 2× cleavage sequence-containing Mpro biosensor. …”
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Preoperative Bevacizumab Does Not Significantly Increase Postoperative Complication Rates in Patients Undergoing Hepatic Surgery for Colorectal Cancer Liver Metastases
Published 2008“…Purpose Although bevacizumab (BV) increases survival rates when used with chemotherapy (CTX) in patients who have metastatic colorectal cancer (CRC), an increase in wound complications has been observed in patients who undergo surgery while receiving BV. …”
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A clustering metaheuristic for large orienteering problems
Published 2022“…The metaheuristic aims to dramatically improve the computation time of a given Orienteering Problem algorithm without a significant decrease in the solution quality of that algorithm, especially for large Orienteering Problems. …”
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
Published 2021“…To be able to solve large problem instances corresponding to real-world applications of the model, a metaheuristic approach is investigated. …”
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Intelligent Rapidly-Exploring Random Tree Star Algorithm
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Effect of heating rate on the pyrolysis of camel manure
Published 2022“…The results indicated that the increase in heating rates increased the starting and ending temperatures (decomposition) of manure components. …”
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On the effects of user ratings on the profitability of cloud services
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Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic anal...
Published 2020“…Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. …”
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The thioredoxin homolog YbbN functions as a chaperone rather than as an oxidoreductase
Published 2008“…It increases 4-fold the rate of protein renaturation in vitro by the DnaK chaperone machine, suggesting that it cooperates with DnaK for the optimal expression of several cytoplasmic proteins.…”
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Shear Strength Behaviors of Tire Shred-Dune Sand Admixtures
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Effect of the stretch rate during uniaxial testing on the mechanical properties of prolene
Published 2017“…Statistically significant findings suggest an increasing trend for Prolene® stiffness vs. stretch rate (R2 = 0.9679; two-tailed p value = 0.0025) where the stiffness increases 26.2% when increasing the displacement rate from 1 to 500 mm/min. …”
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An optimal formulation for test scheduling network-on-chip using multiple clock rates
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Monitoring the variation of soil quality with sewage sludge application rates in absence of rhizosphere effect
Published 2020“…The dose-dependent improvement of organic matter content was the most significant event that reflected sludge application rates, and consequently influenced other soil properties. …”
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