P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis by Milane, Aline

“…The lack of response to treatment in ALS may be, at least in part, due to increased activities of efflux pumps in relation to disease, leading to subtherapeutic brain concentrations of drugs. …”
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Characterizing the Effect of Arginine Deprivation on Autophagic Response in Breast Cancer cells by Haidar, Fatemah

“…Residual ASS1 tumor expression corelated with increased metastasis and decreased survival in patient luminal A, Her2+ and triple-negative breast cancer. …”
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Investigating the Therapeutic Effects of Small Molecule Imipridones In Pediatric Neuroblastoma by El Soussi, Sarra

“…The protein expression of Sox-2, Oct-4, FABP5 and HMGA1 was significantly reduced whereas cleaved PARP1 and caspase-3 and p-H2AX was increased 48 h after drug treatment in the MYCN-amplified IMR-32 cell line. …”
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Optimizing clopidogrel dose response by Saab, Yolande B.

“…Results The study results show that all patients under clopidogrel treatment, whose genotypes are different from *1*1, and concomitantly taking other drugs metabolized by CYP2C19 require clopidogrel dose adjustment. To get a therapeutic effect and avoid adverse drug reactions, therapeutic dose of 75 mg clopidogrel, for example, should be lowered to 6 mg or increased to 215 mg in patients with different genotypes. …”
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Skin responses to fractional photothermolysis by Tannous, Zeina

“…Background and Objective Fractional photothermolysis (FP) is a new concept using arrays of microscopic thermal damage patterns to stimulate a therapeutic response. We analyzed epidermal and dermal response to FP with the aim of correlating histological and clinical response. …”
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Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications by Anthony K. Akobeng (7713470)

“…Dysbiotic microbiota may lead to a dysregulated immune response that may contribute to the pathogenesis of coeliac disease. …”

Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors by Naila Rabbani (291722)

“…Increased MG glycation produces inactivation and misfolding of proteins, cell dysfunction, activation of the unfolded protein response, and related low-grade inflammation. …”

Decoding the Therapeutic Potential of [HuArgI (Co)-PEG5000] Arginase Treatment by Zeineddine, Mira

“…Moreover, our study results lay the groundwork for the creation of innovative combination treatments that specifically target different facets of cancer cell behavior, offering patients with breast cancer better prognoses and increased therapeutic efficacy.…”
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FoxP3⁺ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets by Reem Saleh (3513056)

“…They maintain immune homeostasis and inhibit immune responses in various diseases, including cancer. Proportions of Tregs in the peripheral blood of some cancer patients increase by approximately two-fold, compared to those in healthy individuals. …”

Ultrasound-responsive Nanocarriers in Cancer Treatment: a review by Awad, Nahid S.

“…Using smart nanocarriers, the rate of release of the entrapped therapeutic(s) can be increased, and greater exposure of the tumor cells to the therapeutics can be achieved when the nanocarriers are exposed to certain internally (enzymes, pH and temperature) or externally applied (light, magnetic field, and ultrasound) stimuli that trigger the release of their load in a safe and controlled manner, spatially and temporally. …”
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The Obesity Paradox in Cancer, Tumor Immunology, and Immunotherapy: Potential Therapeutic Implications in Triple Negative Breast Cancer by Adviti Naik (673163)

Recombinant Adeno-Associated Virus-Mediated In Utero Gene Transfer Gives Therapeutic Transgene Expression in the Sheep by Abi Nader, Khalil

“…Plasma hFIX levels then dropped as fetal liver and lamb weights increased, although low levels were detected 6 months after late gestation injection (75 and 52.5 ng/ml, n = 2). …”
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Acoustically activated release of estrone-targeted liposomes used for breast cancer treatment by Mohammad, Najla

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Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications by Fang Yu (156838)

“…The hypertension is not due to increased vascular smooth muscle contractility or vascular remodelling.…”

Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes by Tracy Augustine (14149932)

“…<p>The hygiene hypothesis has been popularized as an explanation for the rapid increase in allergic disease observed over the past 50 years. …”

Editorial: Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer by Said Dermime (79420)

“…One promising emerging approach is to focus on dynamic biomarkers, which would allow, when tested in the patient early after exposition to the therapeutic agents, to identify those patients presenting an immune response failure. …”

Potential mechanisms of human recombinant arginase I (Co)-PEG5000 [HuArgI (CO) - PRG5000] induced cytotoxicity in glioblastoma cells. (c2018) by El Jawhari, Yassmine

“…The addition of chloroquine, an autophagy inhibitor, increased the sensitivity of cells to [HuArgI (Co)-PEG5000]-mediated arginine depletion at earlier time points. …”
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Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017) by Khalil, Nathalie

“…It is also important to mention that we noticed an increase in the percent of surviving cells among completely auxotrophic cell lines postaddition of citrulline at 72, 96 and 120 hours of drug incubation. …”
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Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines by Mazhar Pasha (11197767)

“…Persistently activated HIF-1α is associated with increased cell proliferation, angiogenesis, and epithelial–mesenchymal transition (EMT), consequently leading to ccRCC progression and metastasis to other organs. …”

Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy by Afsheen Raza (492657)

“…We propose that combination therapy to increase the efficacy of NY-ESO-1 specific immunotherapeutic interventions should be explored to unleash the immune response against NY-ESO-1 expressing tumors.…”