A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”

Enhanced optical properties of <i>β</i>-Ga₂O₃-_<em>x</em>S_<em>x</em>S: A DFT study by G.B. Eshonqulov (22927297)

“…Here, we conduct systematic density functional theory calculations to study the effect of sulfur doping on the electronic and optical properties of <i>β</i>-Ga₂O₃. We find that the band gap of the material decreases with increasing sulfur content (from 4.81 eV to 1.59 eV), accompanied by symmetric shifts in both the valence-band offset and the conduction-band edge. …”

Production of flexible nanocomposite membranes for x-ray detectors by Ahmad I., Ayesh

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Production of flexible nanocomposite membranes for x-ray detectors by Ahmad I. Ayesh (10188469)

Correlating the rheological and magneto-optical properties of cobalt substituted magnetite ferrofluids (Co_xFe_1−xFe₂O₄) with theoretical... by Blessy Babukutty (17871482)

“…Faraday rotation of Co_xFe_1−xFe₂O₄ ferrofluids is measured depending on the different concentrations of cobalt in applied magnetic field. …”

Optical coherence tomography findings in autoimmune retinopathy by Abazzari, Azin

“…Results Outer retinal abnormalities and/or decreased macular thickness on OCT were seen in all patients. …”
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Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation by Zreik, Tony

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A Scoping Review to Find Out Worldwide COVID-19 Vaccine Hesitancy and Its Underlying Determinants by Md. Rafiul Biswas (17293966)

“…Methods: PRISMA Extension for Scoping Reviews (PRISMA-ScR) guidelines were followed to conduct a scoping review of literature on COVID-19 vaccine hesitancy and willingness to vaccinate. Several databases (e.g., MEDLINE, EMBASE, and Google Scholar) were searched to find relevant articles. …”

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle by Jinit, Masania

“…This may be achieved by decreasing protein glycation by the reactive metabolite, methylglyoxal (MG). …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle by Jinit Masania (7164239)

“…This may be achieved by decreasing protein glycation by the reactive metabolite, methylglyoxal (MG). …”

Finding novel targets for the treatment and reversal of type 2 diabetes mellitus and obesity by Imran Ramzan (15430807)

“…</p> <p>Results: The BCAA-restricted diet significantly reduced circulating BCAA concentrations by ~50% i.e., baseline 437 ± 60 to 217 ± 40 µmol/L (p < 0.005). …”

Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31 by Jonathan D. J. Labonne (18090841)

“…Using another affected member, DGDP289B, with a microdeletion at Xp22.31, in this family, we performed the genomic and clinical delineation with six published and nine unreported cases. We propose HDHD1 and PNPLA4 for X-linked intellectual disability in this region, since their high transcript levels in the human brain substantiate their role in intellectual functioning.…”

Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors by Noura Aldous (15429873)

“…Single-cell analysis revealed high RFX6 expression levels in endocrine clusters across various hESC-derived pancreatic differentiation stages. Upon differentiating iPSCs lacking RFX6 into pancreatic islets, a significant decrease in PDX1 expression at the PF stage was observed, although this did not affect PPs co-expressing PDX1 and NKX6.1. …”

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex by Wesam S. Ahmed (10170053)

“…Here, we dissect the mechanism underlying the increased binding affinity of the N501Y mutant for ACE2 using molecular dynamics (MD) simulations of the available ACE2-S1-RBD complex structure (6M0J) and show a prolonged and stable interfacial interaction of the N501Y mutant S1-RBD with ACE2 compared to the wild type S1-RBD. Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”

Correlations between Resting Electrocardiogram Findings and Disease Profiles: Insights from the Qatar Biobank Cohort by Fatima Qafoud (14778571)

“…Elevated QTc was observed in CAD patients, whereas decreased QTc was correlated with decreased levels of calcium and potassium. …”

Effects of vitamin E derivatives on the proliferation of KG-1 leukemic cells in vitro by Rizk, Sandra

“…XTT cell viability assay, which detects the presence of metabolically active cells, was used to assess cell proliferation. A decrease in proliferation of KG-1 cells was observed upon treatment with both forms of vitamin E derivatives; however, β-T3 was more potent than γ-T3 in promoting cell death with lower IC50 values. …”
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The burden of prostate cancer in North Africa and Middle East, 1990–2019: Findings from the global burden of disease study by Mohsen Abbasi-Kangevari (9714440)

DNA methylation signature in peripheral blood reveals distinct characteristics of human X chromosome numerical aberrations by El Maarri, Osman

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Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 2021 by Letourneau, Ian D

“…YLLs and YLDs were summed to estimate disability-adjusted life-years (DALYs). FindingsIn 2021, the global age-standardised mortality rate of appendicitis was 0·358 (95% uncertainty interval [UI] 0·311–0·414) per 100 000. …”
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Electrochemical and thermodynamic study on the corrosion performance of API X120 steel in 3.5% NaCl solution by Khuram Shahzad (575887)

“…The overall results revealed that PEI significantly decreases the corrosion rate of API X120 steel with inhibition efficiency of 94% at a concentration of 100 μmol L⁻¹. …”