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    Association between Insulin and Nitric Oxide in Human Retinal Microvascular Endothelial Cells in vitro

    Association between Insulin and Nitric Oxide in Human Retinal Microvascular Endothelial Cells in vitro by Rizk, Nasser Moustafa

    Published 2016
    “…Insulin treatment caused an up regulation of IRS-1 and IRS-2 genes after 1 hour however, PI3K, Akt and eNOS were significantly reduced. The analysis of angiogenic and proapoptotic markers VEGFA and NFkB by RT-PCR showed no significant change in the expression of NFkB in hyperglycemic alone, hyperglycemic and normoglycemic cells with insulin treatment at all-time points. …”
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