Published 2020
“…Compared with control, we found in STZ-rats with established pain hypersensitivity (
5 weeks post-STZ) several significant changes including: (
a)
A 23% increase in the incidence of spontaneous activity (SA) in
Aβ-LTMs (but not C-mechanosensitive nociceptors) that may cause dysesthesias/paresthesia suffered by DPNP patients, (
b) membrane hyperpolarization and
a ∼85% reduction in SA rate in
Aβ-LTMs by K7 channel activation with retigabine (6 mg/kg, i.
v.) suggesting that K7/M channels may be involved in mechanisms of SA generation in
Aβ-LTMs, (c)
decreases in AP duration and in duration and amplitude of afterhyperpolarization (AHP) in C-and/or
Aβ-nociceptors. …”
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