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Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies
Published 2021“…Melanoma is an aggressive skin cancer with a high rate of metastasis to other organs. Recent studies specified the overexpression of V-domain Ig suppressor of T-cell activation (VISTA) and Aryl Hydrocarbon Receptor (AHR) in melanoma. …”
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Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies
Published 2021“…Melanoma is an aggressive skin cancer with a high rate of metastasis to other organs. Recent studies specified the overexpression of V-domain Ig suppressor of T-cell activation (VISTA) and Aryl Hydrocarbon Receptor (AHR) in melanoma. …”
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Deregulation of cell growth and apoptosis in UV-induced melanomagenesis
Published 2020“…Our results showed that melanocytes expressed p16 only at a high UVB dose, with undetectable p53. …”
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A Reconfigurable Multipurpose SoC Mobile Platform for metal detection
Published 2018“…Zaman, «Efficient design of a metal detector equipped remote-controlled robotic vehicle,» 2016 International Conference on Microelectronics, Computing and Communications (MicroCom), Durgapur, 2016, pp. 1-5 [3] «Cyclone V Device Overview», Altera, 2016. …”
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Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Published 2019“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
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Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines
Published 2018“…Treatment with GC suppressed constitutively phosphorylated AKT and downregulated expression of inhibitor of apoptotic proteins XIAP, cIAP-1, and cIAP-2. In summation to this, GC-treated leukemic cells upregulated protein expression of pro-apoptotic proteins, Bax with concomitant decrease in expression of anti-apoptotic proteins including Bcl-2 and Bcl-xL. …”
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L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats .
Published 2020“…Here, we recorded somatic action potentials (APs) intracellularly from C- and A-fiber L4/L5 DRG neurons to examine our hypothesis that L5-SNA would induce distinct electrophysiological changes in the two populations of DRG neurons. …”
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An Eco-Friendly Quaternary Ammonium Salt as a Corrosion Inhibitor for Carbon Steel in 5 M HCl Solution: Theoretical and Experimental Investigation
Published 2022“…This study aims to investigate the performance of an environment-friendly Quaternium-22 (Q-22) surfactant which is widely used in cosmetics for C-steel corrosion inhibition in a 5 M HCl medium. …”
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Ferroelectric Properties and Electrocaloric Effect in Dy2O3 Substitution on Lead-Free (Na0.5 Bi0.5)0.94 Ba0.06TiO3 Ceramic
Published 2023“…Higher stability of the ferroelectric (FE) phase was obtained at room temperature for the compositions y = 0.01, 0.02 and 0.05, with optimum values for y = 0.02 as remanent polarization Pr = 32µC/cm2, as well as piezoelectric coefficients d33 = 137 pC/N, kp = 0.27 and kt = 0.16, whereas a higher content of Dy (y = 0.08) induced a remarkable decrease of the ferroelectric and piezoelectric properties. …”
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Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Supplementation Alters Gut Microbiome and Corrects Dyslipidemia in Rats.
Published 2019“…Wistar rats were offered a chow maintenance diet (CMD; CON group) or the same CMD ration with cholesterol (1.5% w/w) and cholic acid (0.5% w/w) added to induce hypercholesterolemia (day 1 to day 24). …”
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Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart
Published 2014“…Our results showed that mercury treatment caused a significant induction of the cardiac hypertrophy markers, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP); in addition to Cyp1a1, Cyp1b1, Cyp2b9, Cyp2b10, Cyp2b19, Cyp2c29, Cyp2c38, Cyp4a10, Cyp4a12, Cyp4a14, Cyp4f13, Cyp4f15, Cyp4f16 and Cyp4f18 gene expression. …”
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Microstructure, wear and corrosion characteristics of Cu matrix reinforced SiC–graphite hybrid composites
Published 2019“…Copper matrix composites with SiC-graphite reinforcement (0, 2.5,5, 7.5 and 10 wt.%) were prepared by stir casting process. …”
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Enhancement of mechanical and corrosion resistance properties of electrodeposited NiP-TiC composite coatings
Published 2021“…Various amounts of TiC particles (0, 0.5, 1.0, 1.5, and 2.0 g L−1) were co-electrodeposited in the Ni–P matrix under optimized conditions and then characterized by employing various techniques. …”
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Enhancing thermal and mechanical response of aluminum using nanolength scale TiC ceramic reinforcement
Published 2018“…The CTE of Al composite decreased with the progressive addition of hard TiC nanoparticles. …”
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