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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Chemical biology approaches using small molecule inhibitors targeting specific signaling pathways are useful tools to dissect the molecular mechanisms governing stem cell differentiation and for their possible use in therapeutic interventions. …”
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Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex
Published 2022“…This sentence previously stated:</p><p dir="ltr">“Representative trajectory movies of the 10 ns simulations were prepared from 5,000 trajectory snapshots (50 snapshots/ns) generated using VMD Movie Maker Tool (Humphrey et al., 1996) and compiled using Fiji distribution of ImageJ software (Schindelin et al., 2012) at a frame rate of 300 fps.”…”
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Decreased phosphodiesterase activities in cardiac hypertrophy
Published 2007“…Cyclic nucleotide-gated (CNG) channels were used to monitor cAMP. The whole cell patch-clamp technique was used to record the associated CNG current (ICNG) and ICa,L. …”
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Decreased Expression and Activity of cAMP Phosphodiesterases in Cardiac Hypertrophy and Its Impact on β-Adrenergic cAMP Signals
Published 2009“…Engineered cyclic nucleotide-gated (CNG) channels were expressed in single cardiomyocytes to monitor subsarcolemmal cAMP using whole-cell patch-clamp recordings of the associated CNG current (ICNG). …”
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The Protective Effects of Daucus carota L. ssp. carota and Cannabis sativa L. Extracts against Cisplatin Induced Nephrotoxicity in Animal Models
Published 2021“…Serum creatinine and urea, proteinuria, and inflammatory markers were measured. All used doses of COE showed significant decrease in serum urea; however, a significant decrease in serum creatinine was observed only at 20 mg/kg COE. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Mutation of the two residues in NLuc revealed a decreased but stable activity of the R162A, but not Q32A, mutant NLuc in live cell and in vitro assays performed using lysates prepared from cells expressing the proteins and with the furimazine substrate. …”
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Using B<sub>4</sub>C Nanoparticles to Enhance Thermal and Mechanical Response of Aluminum
Published 2017“…The porosity of the composites increased whereas density decreased with increasing B<sub>4</sub>C content. Electron microscopy analysis reveals the uniform distribution of B4C nanoparticles in the Al matrix. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Here, we dissect the mechanism underlying the increased binding affinity of the N501Y mutant for ACE2 using molecular dynamics (MD) simulations of the available ACE2-S1-RBD complex structure (6M0J) and show a prolonged and stable interfacial interaction of the N501Y mutant S1-RBD with ACE2 compared to the wild type S1-RBD. …”
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Empiric antibiotic therapy of community-acquired Pneumonia at the American University of Beirut Medical Center. (c2001)
Published 2001“…Initial antimicrobial regimen was defined as all antibiotics used during the first 48 hours of hospitalization. …”
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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
Published 2025“…We envisage that the NB2E3 nanobody-2× Mpro biosensor engineered here will be useful in drug discovery and functional characterization of Mpro mutants in newly emerging SARS-CoV-2 variants as well as in detecting SARS-CoV-2 infection in a point-of-care testing (POCT) format.…”
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Nasturtium officinalis water extract. (c2009)
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Accelerating Care: Enhancing Patient Satisfaction through a Quality Initiative in the Obstetrics and Gynaecology Emergency Department at Al Wakra Hospital, Qatar
Published 2023“…The proportion of patients spending less than 8 hours in the OB ED observation beds rose from 74% in January 2022 to over 98% in 2023. Notably, there was a remarkable decrease in patients who Left Without Being Seen (LWBS) and in absconded patient rates from 2020 to 2023 (Figure 2).…”
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Geomorphological changes in the coastal area of Farasan Al-Kabir Island (Saudi Arabia) since mid Holocene based on a multi-proxy approach
Published 2018“…The geomorphological evolution of the southeastern coastal area of Farasan Al-Kabir Island (Saudi Arabia) is revealed by the mapping of modern landforms and a multi-proxy and high spatial resolution study including grain size, particulate organic carbon, mineralogy, element geochemistry, benthic foraminifera analysis and radiocarbon dating of a 3.3-m long sediment core. …”
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