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LDL-C Targets in Secondary Prevention: How Low Should We Go?
Published 2019“…<h3>Abstract</h3><p dir="ltr">The benefits of lowering low-density lipoprotein cholesterol (LDL-C), mainly using high-intensity statin therapy, and its impact on decreasing the recurrence of atherosclerotic cardiovascular disease (ASCVD) in secondary prevention has been well established. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the affected signaling networks were TGFβ1, SPP1, and ERK regulatory networks. Conclusions. We identified γ-secretase inhibitor (LY411575) as a potent regulator of osteoblastic differentiation of hBMSC that may be useful as a therapeutic option for treating conditions associated with ectopic bone formation.…”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…PP2A, GSK3β and Tau reside together in a complex, which facilitates their interaction and (dys)-function as has been reported for several neurological disorders. In this study we recorded maximum increase in total PP2A at 3 µM sodium selenate in a neuron cell line. …”
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Green Inhibition of Mild Steel Corrosion in a CO2 Saturated Saline Solution
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Production and investigation of flexible nanofibers of sPEEK/PVP loaded with RuO2 nanoparticles
Published 2021“…<p dir="ltr">Electrospinning technique was employed to fabricate composite nanofibers/nanoparticles of sulfonated polyether ether ketone, polyvinylpyrrolidone, and ruthenium oxide (sPEEK/PVP/RuO<sub>2</sub>). The samples were synthesized with different concentrations of hydrous ruthenium chloride of 2 wt%, 5 wt%, and 10 wt%, and then annealed at a temperature of 300 °C for 4 h to form the ruthenium oxide nanoparticles. …”
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Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis
Published 2025“…</p><h3>Methods</h3><p dir="ltr">Wild‐type (WT) and LAT2 knock‐out (LAT2KO) mice were exposed to short‐ and long‐periods of fasting (16 and 48 h). …”
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Enhanced thermoelectric properties of Bi<sub>2</sub>Te<sub>2.55</sub>Se<sub>0.45</sub> nanocomposites using eco-friendly Eocene Midra Shale palygorskite nanofillers: A sustainable...
Published 2025“…The calculated ZT profile showed that EMS can improve the thermoelectric properties only when added in small amounts of 0.05 wt%. The figure-of-merit of the 0.05 wt% sample reached 0.89 at 150 °C, resulting in 19 % improvements compared to the pristine Bi<sub>2</sub>Te<sub>2.55</sub>Se<sub>0.45</sub> pellet measured at the same temperature. …”
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Biodegradable polysaccharide grafted polyacrylamide inhibitor for corrosion in CO<sub>2</sub>- saturated saline solution
Published 2023“…Electrochemical tests of Tafel and AC impedance, were used to determine the corrosion rate of carbon steel (C-steel) and protection efficiency in CO<sub>2</sub>-saturated 3.5 wt% NaCl solution. The surface morphology was characterized using FESEM coupled with EDX. …”
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Improvement of the Superconducting Properties of GdBa2Cu3O7-δ with Nano-Sized Ferrite Addition
Published 2019“…We have been investigating the effect of (CoFe2O4)x and (ZnFe2O4)x (x is the wt%) nano-sized ferrites on the superconducting (SC) properties of the high-Tc SC compound GdBa2Cu3O7-δ (Gd123) prepared by the conventional solid-state reaction technique. …”
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1,2,4-Trimethylbenzene Transformation Reaction Compared With Its Transalkylation Reaction With Toluene Over USY Zeolite
Published 2020“…Reaction mixtures of 50:50 wt % TMB and toluene were used for the transalkylation reaction. …”
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