Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice by Julie Decock (44558)

“…We have intercrossed Mmp8-null mice with the Polyoma virus middle T oncogene-driven (MMTV-PyMT) mouse model of mammary cancer to explore the effects of loss of MMP-8 on the incidence and progression of mammary carcinomas. …”

Cerebrospinal α‐Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort by Nour K. Majbour (8809316)

Resveratrol-Elicited PKC Inhibition Counteracts NOX-Mediated Endothelial to Mesenchymal Transition in Human Retinal Endothelial Cells Exposed to High Glucose by Roberta Giordo (299595)

“…Treatment of HRECs with HG increased intracellular ROS levels and promoted phenotype shifting towards EndMT, evidenced by decreased expression of endothelial markers concomitant with increased expression of mesenchymal ones. …”

Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells by Sleiman, S.

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The contribution of autophagy in glioblastoma multiforme cells treated with human recombinant arginase I-induced arginine deprivation. (c2018) by El Jbeily, Elie

“…Furthermore, the contribution of autophagy to arginine depletion-induced cytotoxicity in GBM cells was tested by incubating SF and U87 cells with either HuArgI (Co)-PEG5000 alone and in combination with an autophagy inhibitor (chloroquine or 3- methyladenine) at different time points. Cell death decreased when autophagy was inhibited in SF cells at late time points, thus proving its role in arginine depletion induced cell death. …”
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Recent advances in the treatment and outcome of locally advanced rectal cancer by Abdalla, Eddie

“…Objective To compare the outcomes of treatment of locally advanced rectal cancer of the early era (1975–1990) with those of the late era (1991–1997). Background Preoperative therapy has been used in locally advanced rectal cancer to preserve sphincter function, decrease local recurrence, and improve survival. …”
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo by Daaboul, Hamid E.

“…Flow cytometry analysis revealed that treatment with 10 μg/ml HC significantly increased the number of cells undergoing late apoptosis (28%), while 25 μg/ml caused a larger cell shift towards late apoptosis (46.6%) and necrosis (39%). …”
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The persistence of hippocampal-based memory requires protein synthesis mediated by the prion-like protein CPEB3 by Stephan, Joseph S.

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Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways by Daaboul, Hamid E.

“…Flow cytometry analysis revealed that 10 μg/ml HC increased the number of cells undergoing necrosis (18.05%) and late apoptosis (15.66%). At HC 25 μg/ml more cells shifted toward necrosis (58.01%) and late apoptosis (30.47%). …”
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The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer by El Mais, Nour

“…In this study, we hypothesized that HuArgI (Co)- PEG5000 can decrease the migration of ovarian cancer cells. Our results show a decrease in the migratory rate of the cells and their rate in wound closure. …”
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Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells by El-Sibai, Mirvat

“…Upstream of Arp2/3, Cdc42 knockdown inhibited EGF-stimulated activation of PI 3- kinase at early (within 1 minute) but not late (within 3 minutes) time points. Membrane targeting of N-WASP, WAVE2 and IRSp53 were also inhibited. …”
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Aqueous urtica dioica leaves extract inhibits proliferation of acute myeloid leukemia cells in vitro by Rizk, Sandra

“…To confirm apoptosis, AnnexinV/PI dual staining method was performed showing a time- and dose-dependent increase in the number of cells in the early and late apoptosis stage. With respect to the proteins studied, treatment with Urtica dioica extract significantly increased the expression of the pro-apoptotic protein Bax with concomitant decrease in the anti-apoptotic protein Bcl-2 expression. …”
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Geomorphological changes in the coastal area of Farasan Al-Kabir Island (Saudi Arabia) since mid Holocene based on a multi-proxy approach by Pavlopoulos, Kosmas

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The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis by Daaboul, Hamid E.

“…Papilloma yield, volume, histology, and mice weight and liver function were assessed. HC treatment decreased significantly cell survival (IC50 = 7 and IC90 = 40 μg/ml) and increased significantly cells undergoing late apoptosis and necrosis. …”
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Prehospital plasma transfusion versus standard of care following traumatic injury: a review of the systematic reviews and a meta-analysis by Ayman El-Menyar (440103)

“…PHP did not significantly decrease vasopressor use or late mortality; however, it may reduce the total use of RBCs in the first 24 h. …”

Causes of Delay in Construction Projects in Oil and Gas Construction Industry by FANOUSSE, MARWA IMAD

“…With regard to design, the contractor’s need to decrease construction costs through a cheaper design was found to be a factor in design changes. …”
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Prostaglandin E2 regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1β-treated human synovial fibr... by Faour, Wissam

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Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine by Nader I. Al-Dewik (14152884)

“…Many companies are now focusing on a translational medicinal approach as a therapeutic strategy in decision making upon realizing the expenses of drug attrition in late-stage advancement. In addition, the utility of biomarkers in clinical decision and therapy guidance seeks to improve the patient outcomes and decrease wasteful and harmful treatment. …”

Young bone marrow transplantation delays bone aging in old mice by Lina, Abu-Nada

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Percutaneous Aspiration Irrigation Drainage Technique in the Management of Septic Arthritis in Children by Hayek, Toni

“…A late follow-up phone interview was made for each patient. …”
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