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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…From this and previous transcriptomic studies, signaling involved in enhanced removal of MG-modified protein is likely increased HSPB1-directed HUWE1 ubiquitination through eIF2α-mediated, ATF5-induced increased expression of HSPB1. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…From this and previous transcriptomic studies, signaling involved in enhanced removal of MG-modified protein is likely increased HSPB1-directed HUWE1 ubiquitination through eIF2α-mediated, ATF5-induced increased expression of HSPB1. …”
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Effects of vitamin E derivatives on the proliferation of KG-1 leukemic cells in vitro
Published 2017“…XTT cell viability assay, which detects the presence of metabolically active cells, was used to assess cell proliferation. A decrease in proliferation of KG-1 cells was observed upon treatment with both forms of vitamin E derivatives; however, β-T3 was more potent than γ-T3 in promoting cell death with lower IC50 values. …”
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eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways
Published 2018“…Here we show that hippuristanol, a compound that impedes eIF4A in a manner distinct from PatA, similarly inhibits the iNOS/NO pathway and cytokine-induced muscle wasting. …”
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Connexin 43 Loss Triggers Cell Cycle Entry and Invasion in Non-Neoplastic Breast Epithelium: A Role for Noncanonical Wnt Signaling
Published 2019“…Cell cycle entry and proliferation were enhanced, concomitantly with c-Myc and cyclin D1 upregulation, while no detectable activation of Wnt/β-catenin signaling was observed. Motility and invasion were also triggered and were associated with altered acinar morphology and activation of ERK1/2 and Rho GTPase signaling, which acts downstream of the noncanonical Wnt pathway. …”
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Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway
Published 2022“…Interestingly, the silencing of β-catenin with siRNA abolished the effect of Ex-4 on these genes, suggesting dependency on the Wnt/β-catenin pathway. Additionally, after β-catenin silencing, OA treatment significantly increased the expression of nuclear transcription factors SREBP-1 and TCF4, whereas Ex-4 significantly decreased this upregulation. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. …”
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Fourier-Transform Infrared Imaging Spectroscopy and Laser Ablation -ICPMS New Vistas for Biochemical Analyses of Ischemic Stroke in Rat Brain
Published 2018“…Areas close to the stroke focus experienced decrease in the lipid and lipid acyl contents associated with an increase in lipid ester, olefin, and methyl bio-contents with a novel finding of Aβ1-42 in the PL-GM and L-WM. …”
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Studies on Natural Extracts as Inhibitors of Mild Steel Corrosion in 1M HC1 Solution
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Response of cauliflower (<i>Brassica oleracea</i> L.) to nitric oxide application under cadmium stress
Published 2022“…The present study was conducted using four different genotypes of B. oleracea named as FD-3, FD-4, FD-2 and Ceilo Blanco which were subjected to the Cd stress at various concentrations i.e., 0, 5, 10 and 20 µM with or without the application of NO i.e., 0.10 mM in the sand containing nutrient Hoagland’s solution. …”
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Impact of trace noble metals on the catalytic performance of LaNiMgO towards methane dry reforming
Published 2024“…On the other hand, at the same time-on-stream LaNiMgO-Rh lost 0.3 and 0.7 % of its maximum CO2 and CH4 conversions, respectively.In durability measurements, and after 140h LaNiMgO-Rh exhibited slight decay in the CO2 conversion from 77.6 % to 70.5%, the CH4 conversion decreased from 72.3% to 64.2%. …”
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Impact of trace noble metals on the catalytic performance of LaNiMgO towards methane dry reforming
Published 2024“…In durability measurements, and after 140h LaNiMgO-Rh exhibited slight decay in the CO<sub>2</sub> conversion from 77.6 % to 70.5%, the CH<sub>4</sub> conversion decreased from 72.3% to 64.2%. …”
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Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes
Published 2019“…Dedifferentiation is well characterized by the decrease in expression of key β cell markers such as genes encoding major transcription factors, e.g., MafA, NeuroD1, Nkx6.1, and Foxo1, and an increase in atypical or “disallowed” genes for β cells such as lactate dehydrogenase, monocarboxylate transporter MCT1, or progenitor cell genes (Neurog3, Pax4, or Sox9). …”
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