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Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
Published 2020“…G alleles). Both average rDNA methylation of all analyzed DNA molecules and the number of fully (>50%) methylated alleles, which are thought to be epigenetically silenced, increase with donor's age. …”
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A clustering metaheuristic for large orienteering problems
Published 2022“…The metaheuristic aims to dramatically improve the computation time of a given Orienteering Problem algorithm without a significant decrease in the solution quality of that algorithm, especially for large Orienteering Problems. …”
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Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic anal...
Published 2020“…Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. …”
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
Published 2021“…To be able to solve large problem instances corresponding to real-world applications of the model, a metaheuristic approach is investigated. …”
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Aging Effects in Field-Compacted Dredged Material
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Perinatal factors impacting echocardiographic left ventricular measurement in small for gestational age infants: a prospective cohort study
Published 2023“…<h2>Introduction</h2><p dir="ltr">Infants born small for gestational age (SGA) have an increased risk of developing various cardiovascular complications. …”
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Phosphorus supplementation increases thermic response to glucose solution in healthy lean subjects
Published 2013“…We hypothesised that the addition of P to a glucose load would enhance ATP production resulting in an increase in TEF. To test this hypothesis, we measured the TEF of glucose solution with or without P in seven healthy subjects (3M 4F; Age=21.1±0.8y; BMI= 23.2 ±1.3kg/m2) in a cross over design with 1 week washout period. …”
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Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with age
Published 2012“…Furthermore, in our overall sample, DAT methylation levels increased with age. Interestingly, a separate analysis of patients suggested that this finding was mainly driven by the patient group. …”
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Shear Strength Behaviors of Tire Shred-Dune Sand Admixtures
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Thrombophilic genetic anomalies and their association with dialysis initiation age in a cohort of Lebanese hemodialysis patients
Published 2018“…Homozygous mutations (> 10% of patients) were observed in the PAI-1 (11%), MTHFR A1298C sequence variant (12.7%), and ACE genes (12%); in addition, the FXIII V34L and PAI-1 4G/5G genotypes were significantly associated with early dialysis initiation (P < .001 and P = .004, respectively). …”
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Parallel multi-voltage power minimization in VLSI circuits. (c2013)
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Operation optimization of propane pre-cooled mixed refrigerant LNG Process: A novel integration of knowledge-based and constrained Bayesian optimization approaches
Published 2024“…In addition, the optimized SEC in this study is 14.5 % to 38.6 % lower than those reported in the literature. At large-scale LNG production (10,000 tons per day), the reduction in the SEC is translated into an 18 MW decrease in compression power, saving approximately 4.7 million $ per year for each C3MR train. …”
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