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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …”
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Hyperhydration-induced decrease in urinary luteinizing hormone concentrations of Male athletes in doping control analysis
Published 2019“…Baseline urinary LH concentrations, expressed as the mean � SD for each individual, were within the acceptable physiological range (7.11 � 5.42 IU/L). …”
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Biocorrosion behavior of biodegradable nanocomposite fibers coated layer-by-layer on AM50 magnesium implant
Published 2016“…The results showed that the AJS 3D membrane fiber layers, particularly the hybrid membrane layers containing a small amount of nHA (3wt.%), induce a higher biocorrosion resistance and effectively decrease the initial degradation rate compared with the neat AM50 coupon samples. …”
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Uncovering the Epigenetic Contribution of Protein Arginine Methyltransferase 5 (PRMT5) during Zebrafish Cardiomyogenesis
Published 2020“…The reduction of the expression of PRMT5 also resulted in a 4-fold decrease in the rate of hatching and had negative impacts on locomotion and tail flicking in PRMT5 morphants. …”
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Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Published 2019“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
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Impact assessment of non-indigenous jellyfish species on the estuarine community dynamic: A model of medusa phase
Published 2017“…Low water discharge and low nutrient retention rate appear to be the most favourable conditions for B. virginica. The species is a non-selective predator able to integrate into the system effectively and has caused a decrease in the biomass of other organisms in the estuarine ecosystem throughout the summer after dam removal. …”
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Impact of trace noble metals on the catalytic performance of LaNiMgO towards methane dry reforming
Published 2024“…On the other hand, LaNiMgO-Pd depicted rapid decay in the CO2 conversion from 68.3 % to 49.3 % and the CH4 conversion felled from 66.5 % to 41.5 % after 50h. …”
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Relationship between the heart rate and E/A ratio in athletic and non-athletic males in different ages
Published 2011“…Student t-test was used to establish the differences between transmitral and TDI determined velocities and indices in athletes and non-athletes. Results: The E/A decreased with age, the rate of decrease was slower in the physically trained subjects, except in children. …”
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A CFD- RSM study of cuttings transport in non-Newtonian drilling fluids: Impact of operational parameters
Published 2022“…The current article provides a theoretical study of the impact of three operational parameters on cuttings transport in non-Newtonian drilling fluids. …”
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Repositioning of the global epicentre of non-optimal cholesterol
Published 2020“…Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. …”
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Effective non-intrusive load monitoring of buildings based on a novel multi-descriptor fusion with dimensionality reduction
Published 2020“…This paper presents an efficient non-intrusive load monitoring framework that consists of the following main components: (i) a novel fusion of multiple time-domain features is proposed to extract appliance fingerprints; (ii) a dimensionality reduction scheme is introduced to be applied to the fused time-domain features, which relies on fuzzy-neighbors preserving analysis based QR-decomposition. …”
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How to govern the non-cooperative amateur drones?
Published 2019“…Also, a novel method to build a no-fly zone for non-cooperative drones is proposed.…”
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Non-steroidal anti-inflammatory drugs and bone healing in animal models-a systematic review and meta-analysis
Published 2021“…Trial registration: Protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx…”
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