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Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Published 2019“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
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L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats .
Published 2020“…Conflicting evidence for this may result from some studies assuming that all L4-fibers are undamaged. Here, we recorded somatic action potentials (APs) intracellularly from C- and A-fiber L4/L5 DRG neurons to examine our hypothesis that L5-SNA would induce distinct electrophysiological changes in the two populations of DRG neurons. …”
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Ferroelectric Properties and Electrocaloric Effect in Dy2O3 Substitution on Lead-Free (Na0.5 Bi0.5)0.94 Ba0.06TiO3 Ceramic
Published 2023“…We report the impact of dysprosium (Dy, with y = 0.01, 0.02, 0.05 and 0.08) substitution in (Na0.5 Bi0.5)0.94 Ba0.06TiO3 (NBT-6BT) lead-free ceramics. …”
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Opportunities, challenges and trade-offs with decreasing avoidable food waste in the UK
Published 2021“…Stakeholder interrelations, regulatory and socio-economic aspects are discussed in relation to their influence on decreasing avoidable food waste. The main output from this work is a diagrammatic depiction of where challenges and trade-offs occur along the food supply chain, and how policy and socio-economic reforms are needed to maximise avoidable food waste prevention, and the surplus avoidable food redistribution in the food supply chain for social benefit.…”
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Reducing energy consumption of CO2 desorption in CO2-loaded aqueous amine solution using Al2O3/HZSM-5 bifunctional catalysts
Published 2018“…The aim of this work is to find a potential way for great decrease in CO2 capture energy requirement. Here, for the first time, a series of bifunctional Al2O3/HZSM-5 catalysts (Al-ZSM) were prepared by the combined precipitation ultrasound method and used for the CO2 desorption process. …”
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Turning point in COVID-19 severity and fatality during the pandemic: a national cohort study in Qatar
Published 2023“…Conclusion The conclusion of the first omicron wave was a turning point in the severity of the pandemic. …”
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A new family of boost active neutral point clamped inverter topology with reduced switch count
Published 2021“…A new family of inverter topology for active neutral point clamped (ANPC) is proposed. …”
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A Reconfigurable Multipurpose SoC Mobile Platform for metal detection
Published 2018“…Zaman, «Efficient design of a metal detector equipped remote-controlled robotic vehicle,» 2016 International Conference on Microelectronics, Computing and Communications (MicroCom), Durgapur, 2016, pp. 1-5 [3] «Cyclone V Device Overview», Altera, 2016. …”
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Impact of magnetic dipole on a thermally stratified ferrofluid past a stretchable surface
Published 2019“…This article focuses on the characteristics of a magnetic dipole in a viscous ferrofluid induced by linear stretched surface. …”
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Hyperhydration-induced decrease in urinary luteinizing hormone concentrations of Male athletes in doping control analysis
Published 2019“…Baseline urinary LH concentrations, expressed as the mean � SD for each individual, were within the acceptable physiological range (7.11 � 5.42 IU/L). …”
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Effects of supervisor’s personality on the support, abuse, and feedback provided to junior accountants
Published 2020“…Purpose – Past literature suggests that the performance and turnover of the subordinate are affected by the support, abuse, and feedback provided by the supervisor. In this study, we posit that support, abuse, and feedback in an accounting firm, are in turn, affected by the supervisor’s personality, as defined by the Big Five personality factors. …”
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Uncovering the Epigenetic Contribution of Protein Arginine Methyltransferase 5 (PRMT5) during Zebrafish Cardiomyogenesis
Published 2020“…The reduction of the expression of PRMT5 also resulted in a 4-fold decrease in the rate of hatching and had negative impacts on locomotion and tail flicking in PRMT5 morphants. …”
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Understanding the False Positive of Modified Martensitic Steels in Sweet & Sour Service Conditions Using a Point Defect Model Perspective
Published 2023“…Electrochemical tests were performed using a 1L autoclave holding 35 bar of CO2 gas with and without H2S at temperatures varied from 25 °C to 150 °C in salt brine solutions with a pH of 3.5. …”
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A robust experimental-based artificial neural network approach for photovoltaic maximum power point identification considering electrical, thermal and meteorological impact
Published 2020“…Nonetheless, the consideration of irradiance, electrical, thermal, and weather parameters (scenario IV) yielded higher identification accuracy. The results showed a decrease in the MSE of Vmp by 74.3% (from 1.6 V to 0.411 V), and in the MSE of Imp by 95% (from 4.4e−6 A to 2.16e−7 A), respectively. …”
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