The emergence of new SARS-CoV-2 variant (Omicron) and increasing calls for COVID-19 vaccine boosters-The debate continues by Naushad Ahmad Khan (6406973)

“…The emergence of these VOCs (Alpha, Beta, Gamma, and Delta) variants was responsible for new waves of infections across the entire world [3]. The Delta variant was reported to have increased transmissibility, higher viral load [4] and high rates of reinfection [5]. …”

Optimizing clopidogrel dose response by Saab, Yolande B.

“…Results The study results show that all patients under clopidogrel treatment, whose genotypes are different from *1*1, and concomitantly taking other drugs metabolized by CYP2C19 require clopidogrel dose adjustment. To get a therapeutic effect and avoid adverse drug reactions, therapeutic dose of 75 mg clopidogrel, for example, should be lowered to 6 mg or increased to 215 mg in patients with different genotypes. …”
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The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women by Thozhukat Sathyapalan (704787)

“…</p><h3>Conclusion</h3><p dir="ltr">Soy isoflavones transiently increased rT3 levels within 3 months though reverted to baseline at 6 months. …”

Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet doses by Heba Iqbal (17337667)

“…Aptly, there was a 35% increase in solubility and a significant increase (<i>p</i> < 0.05) in dissolution rates of ibuprofen from 3D printed ASD tablets compared to printed tablets of pure ibuprofen. …”

Development of image quality related reference doses called acceptable quality doses (AQD) in paediatric CT exams in Qatar by Mohammad Hassan Kharita (14158812)

“…<h2>Objectives</h2> <p>To describe first experience of integrating assessment of image quality in paediatric X-ray computed tomography (CT) with analysis of the radiation dose indices to develop reference doses called acceptable quality dose (AQD).…”

Regression Analysis between the Different Breast Dose Quantities Reported in Digital Mammography and Patient Age, Breast Thickness, and Acquisition Parameters by Dhou, Salam

“…Screening mammography is considered the primary imaging modality for the early detection of breast cancer. The radiation dose from mammography increases the patients’ risk of radiation-induced cancer. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... by Wesal Habbab (17346961)

“…In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. In summary, our data reveal that sodium selenate enhances PP2A levels, but reduces catalytic activity of PP2A in a dose dependent manner, which fails to reduce Tau and GSK3β phosphorylation under physiological conditions, indicating an alternative route in the rescue of cell pathology in neurological disorders.…”

The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels by Mansour, Hanine

“…Two out of thirty subjects had shown an increase of serum creatinine of ≥ 0.3mg/dL when receiving maintenance doses greater than 2 grams of vancomycin. …”
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Size Increment During Surveillance in Papillary Thyroid Cancer: Evidence Synthesis and Dose–Response Meta‐Analysis by Mohamed Badie Ahmed (10223510)

“…</p><h3>Conclusion</h3><p dir="ltr">It was concluded that progression over the threshold increases linearly over time at approximately less than 1% per year. …”

Evolution of gastroesophageal reflux disease symptoms after bariatric surgery: A dose–response meta-analysis by Abdel-Naser Elzouki (9376853)

“…<h3>Background</h3><p dir="ltr">Obesity is associated with increased prevalence of gastroesophageal reflux disease, with recent reports suggesting improvement in gastroesophageal reflux disease symptoms and weight loss following bariatric surgical intervention. …”

The Effect of Different Doses of Intravenous Dexmedetomidine on the Properties of Subarachnoid Blockade: A Systematic Review and Meta-Analysis by Mohammad K Al Nobani (16561248)

“…Dexmedetomidine-related side effects were higher in patients receiving larger doses; the incidence of bradycardia was higher (OR=3.53, P<0.001) and incidence of hypotension showed a 1.29 fold increase when compared to the control group (P=0.065).…”

Comparative effectiveness of one versus two doses of COVID-19 vaccines in Qatar: Evidence of converging protection over time by Hiam Chemaitelly (439114)

“…</p><h3 dir="ltr">Results</h3><p dir="ltr">For BNT162b2, single-dose effectiveness against infection increased steadily from 9.9 % (95 % CI: 6.7–13.0 %) in the first two weeks post-vaccination to 71.5 % (95 % CI: 45.5–85.1 %) by month 3, closely approaching the 74.5 % (95 % CI: 72.9–76.0 %) effectiveness observed after the two-dose primary series. …”

A cost-effectiveness analysis for high versus standard (low) dose caffeine for the treatment of apnea in neonatal intensive care unit by Eilan Al-Hersh (21841532)

“…</p><h3>Methods</h3><p dir="ltr">From the hospital perspective of Hamad Medical Corporation (HMC), Qatar, a cost-effectiveness decision-analytic model was constructed to follow the use of a HD maintenance caffeine of 20 mg/kg/dose versus a LD maintenance caffeine of 10 mg/kg/dose, in a simulated cohort of AOP neonates, over a therapy follow-up duration of six weeks, until neonatal intensive care (NICU) discharge. …”

Thymoquinone from Nigella sativa seeds promotes the antitumor activity of noncytotoxic doses of topotecan in human colorectal cancer cells in vitro by Khalife, Rana

“…Topotecan, a topoisomerase I inhibitor, is an anticancer drug widely used in the therapy of lung, ovarian, colorectal, and breast adenocarcinoma. Due to the primary dose-limiting toxicity of topotecan, which is myelosuppressive, it is necessary to identify other chemotherapeutic agents that can work synergistically with topotecan to increase its efficacy and limit its toxicity. …”
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Anti-xa guided enoxaparin thromboprophylaxis is associated with less thromboembolism than fixed dose dalteparin in trauma patients admitted to intensive care by Ahmad Kloub (16855149)

“…However, it did not reach statistical significance. 75% of patients with VTE had low anti-Xa levels, while 20% of those with bleeding had high anti-Xa levels.</p><h3>Conclusion</h3><p dir="ltr">Among adult patients in the trauma ICU, compared to a fixed dose dalteparin, enoxaparin prophylaxis with dose calibration according to peak anti-Xa levels was associated with lower VTE rates without increasing the risk of bleeding. …”

Increased Frequency of Severe Hypoglycemia with the Modified-Release Gliclazide Compared to Glimepiride in Diabetic Older Adults; Propensity Score-Adjusted Analysis by Ahmed Fouad Algendy (18102706)

“…We did a subgroup analysis for low and moderate-high doses users. </p><h3>Results</h3><p dir="ltr">We included 2320 patients, 1786 were on gliclazide MR while 534 were on glimepiride. …”

The impact of automatic tube current modulation related settings of a modern GE CT scanner on image quality and patient dose; details do matter by Ioannis A. Tsalafoutas (14776939)

“…</p><h3>Conclusion</h3><p dir="ltr">SmartmA is a tool that if not properly used may increase the patient doses considerably. …”

Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in... by Eleftheria Lefkou (17052414)

“…<h3>Objectives</h3><p dir="ltr">A previous pilot study showed that pravastatin supplementation improved pregnancy outcomes in women with obstetric antiphospholipid syndrome (OAPS) that developed placental insufficiency despite standard of care treatment low molecular weight heparin plus low dose aspirin (LMWH + LDA). …”

Association Between Three-Months Vitamin D Supplementation and Depressive Symptomatology incidence among Saudi Arabian Adults by Khaddaj, Rashel

“…Furthermore, the change between both groups was significantly different (-7.61 ±4.03 in the Vitamin D group, -3.50±1.54 in the control group; p=<0.001) Conclusion: The present study shows thata 50.000 IU/week dose of vitamin D supplementation for 3 months was enough to increase vitamin D levels beyond sufficient and decrease depression symptoms in Saudi Arabian Adults. …”
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Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1 by Natalie C Galles (9715361)

“…Third-dose polio vaccine (Pol3) coverage also increased, from 42·6% (41·4–44·1) in 1980 to 79·8% (78·4–81·1) in 2019, and global coverage of newer vaccines increased rapidly between 2000 and 2019. …”