DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation by Abdelilah Arredouani (10914455)

“…<p>Failure of the heat shock response is a key event that leads to insulin resistance and type 2 diabetes. …”

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes by Shadi Nejat (19457212)

“…<p dir="ltr">Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant with increased metabolic stress. …”

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue by Ali Tiss (437068)

“…<p dir="ltr">Obesity is characterized by a chronic low-grade inflammation and altered stress responses in key metabolic tissues. Impairment of heat shock response (HSR) has been already linked to diabetes and insulin resistance as reflected by decrease in heat shock proteins (HSPs) expression. …”

Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies by Sabah Nisar (12561961)

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle by Jinit, Masania

“…Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health. This may be achieved by decreasing protein glycation by the reactive metabolite, methylglyoxal (MG). …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle by Jinit Masania (7164239)

“…<p dir="ltr">Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health. This may be achieved by decreasing protein glycation by the reactive metabolite, methylglyoxal (MG). …”

From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease by Ahmad Raza (18205961)

Dicarbonyl stress, protein glycation and the unfolded protein response by Naila Rabbani (291722)

“…An optimized inducer of Glo1 expression, trans-resveratrol and hesperetin combination, normalized increased MG concentration, corrected insulin resistance and decreased low grade inflammation in overweight and obese subjects. …”

Welding of Semiconductor Nanowires by Coupling Laser-Induced Peening and Localized Heating by Kelly M. Rickey (19568770)

“…The morphology results show that laser peening can decrease porosity and bring nanowires into contact and pulsed laser heating fuses those contacts. …”

Comparative study of the parameters affecting the performance of microchannels' heat exchangers: Latest advances review by Muhammad Asim (2235472)

“…This study presents the evaluation of performance parameters and the manufacturing aspects of microchannel heat exchangers. This study also examines how microchannel heat exchangers are affected by several parameters, including the type of working fluid used, Brownian motion, geometry of the channel, Reynolds number, Nusselt number, Knudsen number, wall resistance of the channel, the effect of gravity, and inlet and outlet arrangement for fluid. …”

Heat transfer measurements of Polyalpha-Olefin- boron nitride nanofluids for thermal management and lubrication applications by Ahmad K. Sleiti (14778229)

“…Two competing phenomena affect the heat transfer performance: the increase/decrease in resistance to thermal diffusion sublayer when thermal conductivity increases and viscosity decreases, respectively. …”

Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines by Ismail, Jana

“…Monotherapy with CBD demonstrated a dose-dependent tumor growth inhibition at 72h, with the IC50 being 12.5 μg/ml for OVCAR-3 cell line and 12.3 μg/ml for SK-OV-3 cell line. …”
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Thermally Conductive Polyethylene/Expanded Graphite Composites as Heat Transfer Surface: Mechanical, Thermo-Physical and Surface Behavior by Patrik Sobolčiak (4401364)

“…<p dir="ltr">Composites of high-density polyethylene (HDPE) and expanded graphite (EG) are prepared for heat exchangers in multi-effect distillation (MED) desalination. …”

Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic... by Muhanad Alhujaily (11630107)

“…Spliceosomal gene expression correlated positively with Glo1 in human tumor cell lines and tumors. In clinical chemotherapy of breast cancer, increased expression of Glo1 was associated with decreased patient survival, with hazard ratio (HR) = 1.82 (logrank p < 0.001, n = 683) where upper quartile survival of patients was decreased by 64% with high Glo1 expression.…”

Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination—Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inf... by Naila Rabbani (291722)

“…These findings suggest tRES-HESP counters MG accumulation and protein glycation, decreasing activation of the unfolded protein response and expression of TXNIP and TNFα, producing reversal of insulin resistance. tRES-HESP is suitable for further evaluation for treatment of insulin resistance and related disorders.…”

The Impact of Acute and Chronic Exercise on Immunoglobulins and Cytokines in Elderly: Insights From a Critical Review of the Literature by Maha Sellami (4351159)

“…Strength training for 6-12 weeks did not alter plasma IL-1β, IL-2, IL-6 and TNF-α concentration in healthy elderly adults and patients with chronic-degenerative diseases, while 12 weeks of resistance training decreased muscle TNF-α mRNA in frail elderly individuals. …”

Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy by Ajaz A. Bhat (12984701)

“…The complex and dynamic interactions of the secreted cytokines, chemokines, growth factors, and their receptors mediate chronic inflammation and immunosuppressive TME favoring tumor progression, metastasis, and decreased response to therapy. …”

Graphite and metal nitrate-infused HDPE composites for enhanced thermal performance in energy-efficient building envelopes by Mohammad Amir Khan (23770803)

“…These results point to a scalable approach for developing lightweight corrosion resistant thermal management composites that can be used in the design of energy efficient wall panels and heat-dissipative building materials.…”

Protein Glycation in Plants—An Under-Researched Field with Much Still to Discover by Naila Rabbani (291722)

“…Further research to decrease protein glycation in plants may lead to improved plant growth and assist the breeding of plant varieties resistant to environmental stress and senescence—including plants of commercial ornamental and crop cultivation value.…”

Characterization of Dse1 a candida albicans cells wall protein. (c2009) by Daher, Jalil Y.

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