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DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation
Published 2019“…The ability of DNAJB3 to mitigate ER stress and oxidative stress was also investigated and our data show a significant improvement of both forms of stress. …”
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Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes
Published 2023“…<p dir="ltr">Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant with increased metabolic stress. …”
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Differences in protein expression, at the basal state and at 2 h of insulin infusion, in muscle biopsies from healthy Arab men with high or low insulin sensitivity measured by hype...
Published 2023“…Additionally, we show differences in protein levels from skeletal muscle in low and high insulin sensitivity groups. Therefore, these differences may represent early events for the development of insulin resistance, pre-diabetes, and type 2 diabetes.…”
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Dicarbonyl stress, protein glycation and the unfolded protein response
Published 2022“…Dicarbonyl stress is the metabolic state of abnormal high MG concentration. …”
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Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines
Published 2022“…The combination of CBD with either cisplatin or paclitaxel exhibited a significant antagonistic interaction against SK-OV-3 cell line when compared to individual treatment (CI > 1). However, at high cell growth inhibition rates (95% and 97%), mild synergism is detected (CI < 1) when combining CBD with cisplatin against this specific cell line. …”
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masterThesis -
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Optoelectronic properties of highly porous silver oxide thin film
Published 2021“…The Ag<sub>2</sub>O phase of silver oxide appears after 300 s of oxidation under the same conditions, while the optical transparency of the thin film decreases as plasma etching time increases. The sheet resistance of the final film is influenced by the oxidation time and the plasma application periodicity.…”
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Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic...
Published 2021“…</p><h3>Conclusions</h3><p dir="ltr">We conclude that MG-mediated cytotoxicity contributes to the cancer chemotherapeutic response and targets the spliceosome. High expression of Glo1 contributes to multidrug resistance by shielding the spliceosome from MG modification and decreasing survival in the chemotherapy of breast cancer. …”
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Thermal, electrical, and mechanical properties of highly filled HDPE/graphite nanoplatelets composites
Published 2020“…On the other hand, the degree of crystallinity and melting temperature decreased with GNPs content. The incorporation of GNPs greatly decreased the electrical resistivity by 10 orders of magnitude and 400% increase in thermal conductivity for filled HDPE was also observed. …”
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Evaluation of the durability and shielding properties of high-strength concrete incorporating locally available materials and carbon additives
Published 2026“…High-strength concrete (HSC) has been extensively studied for major applications, particularly in high-rise buildings and bridges. …”
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Removal of bacterial contaminants and antibiotic resistance genes by conventional wastewater treatment processes in Saudi Arabia: Is the treated wastewater safe to reuse for agricu...
Published 2015“…Besides the presence of antibiotic-resistant bacterial isolates, tetracycline resistance genes tetO, tetQ, tetW, tetH, tetZ were also present at an average 2.5 × 102, 1.6 × 102, 4.4 × 102, 1.6 × 101 and 5.5 × 103 copies per mL of chlorinated effluent. …”
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Design and analysis of PV fed high-voltage gain DC-DC converter using PI and NN controllers
Published 2022“…When the converter switch comes under active state two capacitors are discharged in series, similarly when the converter switch under inactive state those two capacitors are charged in parallel through the coupled inductor (CI) energy so, to get a high voltage at the converter output side. To reuse the leakage-inductor (LI) energy of the CI with the help of a passive clamp circuit for reducing the voltage stress across the switch, similarly switch has less resistance so conduction losses also decreased. …”
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Immunoprofile of childhood diabetes
Published 2023“…Associated with these findings, anti-inflammatory Treg cytokines including IL-10 were decreased in T2D patients and elevated plasma levels of IL-17, which contributes to the insulin resistance and inflammation were observed.…”
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Development of eco-friendly coating for the fabrication of high performing loose nanofiltration membranes for dye-contaminated wastewater treatment
Published 2024“…This is further evidenced by SEM, MWCO, and contact angle measurements, which reveal decreased pore size and increased hydrophilicity. The TA/PVA-coated membranes demonstrated high water permeability up to 138 LMH/bar and excellent dye/salt selectivity, achieving ~99 % Congo Red (CR) rejection with <10 % salt rejection in both single-component and dye/salt mixture filtrations. …”
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Whole-Genome Molecular Characterization and Typing of Staphylococcus aureus Isolated from Lebanon
Published 2020“…The rising prevalence of multidrug resistant (MDR) S. aureus in both community and hospital settings is a significant public health concern. …”
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masterThesis -
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Thermally Conductive Polyethylene/Expanded Graphite Composites as Heat Transfer Surface: Mechanical, Thermo-Physical and Surface Behavior
Published 2020“…<p dir="ltr">Composites of high-density polyethylene (HDPE) and expanded graphite (EG) are prepared for heat exchangers in multi-effect distillation (MED) desalination. …”