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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Metaheuristic Algorithm for State-Based Software Testing
Published 2018“…SA evolves a solution by minimizing an energy function that is based on testing objectives such as coverage, diversity, and continuity of events. …”
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Educational Test Scores: Interpretation and Use through an Argument-Based Framework
Published 2025“…The interpretation and use of test scores can significantly privilege some test-takers and disadvantage others if the tests are not valid, that is, not meant for or are not appropriate for the purpose they are used. …”
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An Efficient Test Vector Compression Technique Based on Geometric Shapes
Published 2001“…In this paper, we introduce a novel compression / decompression scheme based on geometric shapes that substantially reduces the amount of test data and reduces test time. …”
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A Testing Framework for Blockchain-Based Energy Trade Microgrids Applications
Published 2024“…This study suggests executing such a testing within a framework that integrates a Geographic Information System (GIS) environment with an Agent-Based Modeling (ABM) simulation platform. …”
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High-sensitive detection and quantitation of thyroid-stimulating hormone (TSH) from capillary/fingerstick and venepuncture whole-blood using fluorescence-based rapid lateral flow i...
Published 2023“…A subgroup analysis of abnormal TSH samples revealed a strong and significant correlation between the reference, Finecare™ whole-blood (r = 0.692; p = 0.0015), and fingerstick test Finecare™ (r = 0.66; p = 0.0025). …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Willingness to participate in genome testing: a survey of public attitudes from Qatar
Published 2020“…The success of a national population-based genome program, like the Qatar Genome Program (QGP), depends on the willingness of citizens to donate samples and take up genomic testing services. …”
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Hemodynamics of small aneurysm pairs at the internal carotid artery
Published 2012“…The maximum wall shear stress increases for serial aneurysms, but decreases for parallel aneurysms. Interaction between parallel aneurysms is not significant; however, the proximal aneurysm in serial aneurysms may be subject to a greater rupture risk.…”
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Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights
Published 2024“…</p><h3>Results</h3><p dir="ltr">2217 patients tested positive for <i>H. Pylori</i> over 3 yrs. of which 837 (37.8 %) were Qatari nationals. …”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
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The Effectiveness of Teaching Reading (Meta) Cognitive Strategies in Improving UAE Grade-12 Students’ Reading Comprehension Proficiency for School-based Tests and University Admiss...
Published 2015“…This study seeks to investigate the effectiveness of strategy-based instruction in improving the reading comprehension proficiency of the UAE grade twelve students in school-based tests and university admission exams like IELTS, TOEFL and CEPA after serious problems regarding reading comprehension have been reported, and many reform procedures have been taken to rectify these problems at university and pre-university levels. …”
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