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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…<p dir="ltr">NanoLuc (NLuc) <u>luciferase</u> has found extensive application in designing a range of <u>biologica</u><u>l</u><u> assays,</u> including <u>gene expression analysis</u>, protein-protein interaction, and protein conformational changes due to its enhanced brightness and small size. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk
Published 2015“…Moreover, a significant smoking-gene interaction is determined with CYP1A1 MspI polymorphism rs4646903 and is associated with a decreased risk of CAD in current smokers (OR 0.52137). …”
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Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss
Published 2018“…Significant decreases in SLC7A8 transport activity was detected for patient’s variants (p.Val302Ile, p.Arg418His, p.Thr402Met and p.Val460Glu) further supporting a causative role for SLC7A8 in ARHL. …”
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Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications
Published 2019“…We found a highly significant association between the <b><i>CCND1</i></b><b> </b><b>rs614367-TT</b> genotype (OR = 5.14; <i>P</i> = 0.004) and TNBC risk, and identified a significant association between the <b>rs614367-T</b> allele and decreased PFS in TNBC. …”
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Exploring of the gender variations in 4Cs skills among primary students
Published 2024“…The purpose of this study was to explore gender differences in 4Cs skills between males and females among the primary students after the execution of an informal program. …”
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Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients
Published 2022“…Platelet counts, on the other hand, dramatically decreased in both IM and (HU + IM).</p><h3>Conclusion</h3><p dir="ltr">Because the studied genes (BCL2, PP2A, CIP2A, and WT1) are participating in cell proliferation and death, the findings show that the examined genes are significant to understand the efficacy of various therapies. …”
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Comparative Analysis of Engagement and Academic Self‐Concept among Nursing Students: Differences in Study Modalities
Published 2024“…</p><h3>Results</h3><p dir="ltr">Significant differences were observed in the USEI scores among the study modalities: online (mean = 45.7, SD = 5.6), hybrid (mean = 48.8, SD = 6.1), and in‐person (mean = 50.4, SD = 6.2), with in‐person students displaying the highest levels of engagement (<i>F</i>= 10.663, <i>P</i>< 0.001). …”
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Differences in Player Position Running Velocity at Lactate Thresholds Among Male Professional German Soccer Players
Published 2019“…<p dir="ltr">This study investigated the differences in running velocities at specific lactate thresholds among male German soccer players. …”
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Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes
Published 2022“…RNA-sequencing analysis further validated the findings by showing a significant increase in genes associated with lipid metabolism, bile acid secretion, and suggested the activation of hepatic stellate cells and hepatic fibrosis in MH lacking FOXA2. …”
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Exploring differences in work values among multigenerational workforce: Leadership approaches in selected higher educational institutions in the UAE
Published 2017“…According to the present thesis, there are significant differences in work values between the three generations in UAE, which in turn differ from the values of employees from the Western countries. …”
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Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4
Published 2023“…</p> <p>Results: Treatment with 200nM Ex-4 for 3h decreased the OA-induced lipid buildup significantly (p<0.05). …”
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Gender-based differences in the prevalence and types of adverse childhood experiences and their associations with psychological distress and perceived lack of safety among adolesce...
Published 2025“…We explored gender differences in prevalence and associations of ACEs with psychological distress and feeling unsafe among Qatari adolescents using a 2017 national cross-sectional survey of 836 students (412 boys and 424 girls) from grades 8 to 12. …”
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
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Gender differences at work
Published 2015“…The findings show that women’s expectations at work were met to a larger extent than men’s. There was a significant difference in at least two HR practices including ‘recognition at work’ and ‘supporting managers/supervisors’. …”
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