-
1
-
2
A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
-
3
-
4
-
5
The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
-
6
-
7
-
8
-
9
Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
-
10
3D Concrete Printing Sustainability: A Comparative Life Cycle Assessment of Four Construction Method Scenarios
Published 2020“…<p dir="ltr">Three-dimensional concrete printing (3DCP) has become recognized as a possible alternative to conventional concrete construction, mainly due to its potential to increase productivity and reduce the environmental impact of the construction industry. …”
-
11
Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
-
12
Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
-
13
-
14
Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
Get full text
Get full text
Get full text
article -
15
Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
Published 2020“…Here, we used bisulfite pyrosequencing and show that methylation of the rDNA transcription unit including upstream control element (UCE), core promoter, 18S rDNA, and 28S rDNA in human sperm also significantly increases with donor's age. This positive correlation between sperm rDNA methylation and biological age is evolutionarily conserved among mammals with widely different life spans such as humans, marmoset, bovine, and mouse. …”
-
16
The Effects of New Public Management on Managers’ Work-Life Balance and Behavior
Published 2020“…The main differing factors included the manner in which NPM was implemented and the negative attitude of the participants when faced with an increasing workload. The key significance of the present study lies in its difference from prior research carried out in other contexts. …”
Get full text
-
17
Modelling of Concrete Waste Using Life Cycle Assessment & Damage Cost
Published 2019“…Therefore, in this study, a Life Cycle Assessment (LCA) was conducted between the current method of landfilling and its transportation of concrete waste to landfill, and the proposed recycling method. …”
Get full text
-
18
-
19
The Influence of Loneliness and Living Alone on the Quality of Life of the Elderly: Evidence from Europe
Published 2023“…This thesis explores the relationship between living alone, loneliness, and quality of life (QoL) in elderly Europeans. This research indicates a positive correlation between living alone and loneliness, with a greater effect on males, and identifies loneliness as an independent factor decreasing QoL. …”
Get full text
-
20
Health-related quality of life as a predictor of tuberculosis treatment outcomes in Iraq
Published 2015“…ResultsAfter the 2-month intensive phase, physical well-being, functional well-being, and the overall total scores were significantly increased (p<0.01). Furthermore, at completion of TB treatment, there were significant improvements in the overall HRQL as indicated by the FACIT-TB total score and all subscales, except social and economic well-being and spiritual well-being. …”
Get full text
Get full text
Get full text
article
