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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A study on crossing speed profiles of pedestrians at signalized crosswalks
Published 2015“…A stepwise speed function is proposed to identify significant sudden changes in individual pedestrian speed profiles. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Cyberbullying Detection and Abuser Profile Identification on Social Media for Roman Urdu
Published 2024“…This paper presents an approach for detecting cyberbullying in Roman Urdu tweets and identifying abuser profiles on Twitter. Firstly, we develop a text corpus of Roman Urdu tweets with user profile data. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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CFD Study of Particle Concentration and Stokes Number Effect on Erosion Profile.
Published 2017Get full text
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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High-Resolution Household Load Profiling and Evaluation of Rooftop PV Systems in Selected Houses in Qatar
Published 2019“…Residential load profiles are typically influenced by seasonal and socio-economic factors. …”
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Thermal profiles of amorphous solid dispersions (ASD) in 3D printed tablets by fused deposition modelling (FDM): Production of tunable tablet doses
Published 2025“…We aimed to simultaneously address these two constraints through application of amorphous solid dispersions (ASD) and additive manufacturing such as Fused Deposition Modelling (FDM) using ibuprofen (IBU) as model drug. …”
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Electrical energy conservation and its application to a sheet glassindustry
Published 1996“…More findings of the application of energy conservation techniques of high significance are presented in the paper…”
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