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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Prevalence and genetic diversity of Blastocystis sp. among autochthonous and immigrant patients in Italy
Published 2023“…This is the first study of Blastocystis sp., its circulating subtypes and allele variability among patients with different geographical origin in an area of Southern Italy, in the Central Mediterranean, characterized by high immigrant pressure. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
Published 2024“…While Qatar's desert land has high land surface temperature, substituting such areas with built-up exhibits a notable rise in temperatures. …”
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Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
Published 2024“…While Qatar's desert land has high land surface temperature, substituting such areas with built-up exhibits a notable rise in temperatures. …”
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The role of protected areas in modulating vegetation response to climatic stressors in hyper-arid ecosystems
Published 2025“…<p>Arid and semi-arid regions are increasingly vulnerable to climate variability, water scarcity, and land degradation, making vegetation health highly sensitive to environmental stressors. In this context, protected areas are a critical conservation strategy. …”
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Meta Reinforcement Learning for UAV-Assisted Energy Harvesting IoT Devices in Disaster-Affected Areas
Published 2024“…<p dir="ltr">Over the past decade, Unmanned Aerial Vehicles (UAVs) have attracted significant attention due to their potential applications in emergency-response applications, including wireless power transfer (WPT) and data collection from Internet of Things (IoT) devices in disaster-affected areas. …”
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Diagnostic accuracy of interleukin-6 (IL-6) as a significant biomarker in late-onset neonatal sepsis: an updated systematic review and meta-analysis
Published 2025“…A bivariate random-effects model was used to estimate pooled sensitivity and specificity, and the area under the SROC curve was used to assess overall diagnostic accuracy. …”
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Adaptive response for climate change challenges for small and vulnerable coastal area (SVCA) countries: Qatar perspective
Published 2023“…As the severity and frequency of climate change impacts and consequences grow fast and highly alarming, particularly for small and vulnerable coastal area (SVCA) countries, the urgency and magnitude of the crises call for immediate and more adaptive responses. …”
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Biologically inspired highly efficient buoyancy engine
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