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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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The Role of Project Management Soft Skills in Increasing Project Success
Published 2017“…As the world economy shifts towards an increasingly globalised market, the degree of competition becomes a more significant challenge which organisations face. …”
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Sustainability within interior design curriculum in UAE & impact on design mindset
Published 2015“…The study showed that after incorporating sustainability in each design class in design III as a field experiment, 38 projects applied sustainability principles on their projects within only 8 weeks. Only 30% of UAE universities are offering obligatory Sustainable courses; therefore the rest 70% of are offering only elective Sustainable courses, which means 70% of our students might take it or might not. 50 % of the universities are offering specialized course, which means it is related to the design practices, and only 20 % integrated sustainability within the requirements of design studio. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment
Published 2018“…Low TRIM28 epithelium to stroma ratios were associated with elevated levels of caspases 3 and 7 in stroma (p = 0.041 and p = 0.036) and an increased signaling pathway similarity in stromal cells with 81 significant Spearman correlations (ρ ≥ 0.75, p ≤ 0.01).…”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Renewable energy options in Saudi Arabia: The economic viability of solar photovoltaics within the residential sector.
Published 2009“…The aim of this paper is to examine the economic viability of using photovoltaics within future residential buildings in the oil-rich Saudi Arabia. …”
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Triple helix components supporting STEM education to increase future STEM careers in the United Arab Emirates
Published 2023“…Further investigation is needed to gain more information about the significant differences in perspectives between and within the stakeholder clusters.…”
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Organizational Change Management: A study on the need for a re-structured organization within a functional configuration
Published 2009“…It will also be concluded that in a functional organization, the introduction of projectized structure for the newly introduced organization may significantly increase the probability of successful outcome from projects.…”
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