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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Experimental Validation of Numerical Model for Thermomechanical Performance of Material Extrusion Additive Manufacturing Process: Effect of Process Parameters
Published 2022“…Finally, the specimens were 3D printed under similar process conditions to validate the numerical model predictions.…”
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Experimental validation of numerical model for thermomechanical performance of material extrusion additive manufacturing process: Effect of infill design & density
Published 2023“…The current practices of the experimental optimization process require significant resources, which can be limited through numerical modeling and simulation techniques. …”
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
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Arabic Translation and Validation of the Adult Oral Health Standard Set Questionnaire
Published 2025“…Cronbach’s alpha coefficient was 0.75, indicating satisfactory internal consistency. For construct validity, Spearman’s rho correlation coefficient ranged from 0.14 to 0.90, indicating a statistically significant correlation with the WHO questionnaire. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Correlating process parameters to thrust forces and torque in the friction stir processing of AZ31B
Published 2014“…An experimental test matrix was used to validate the proposed correlations. The correlation equations were found to be able to predict the experimentally measured forces during friction stir processing with good statistical significance with average estimate errors of 6.2% and 5.4% for the thrust force and torque, respectively. …”
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“Validity and Reproducibility of a Culturally Specific Diet Screener in Evaluating Diet Quality Indices among Adults in Lebanon”
Published 2025“…Rationale: Non-communicable diseases (NCDs) are a leading cause of mortality in Lebanon, with diet playing a significant role in their prevention. Due to the high burden of NCDs, accurate and culturally appropriate dietary assessment tools are needed. …”
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