Novel role of BRCA1 interacting C‐terminal helicase 1 (<i>BRIP1</i>) in breast tumour cell invasion by Balsam Rizeq (14779402)

“…Moreover, down-regulation of <i>BRIP1</i> expression significantly attenuated cell proliferation via cell cycle arrest. …”

Aberrant DNA methylation of <i>PTPRG</i> as one possible mechanism of its under‐expression in CML patients in the State of Qatar by Mohamed A. Ismail (418629)

“…</p><h3>Results</h3><p dir="ltr">CML groups (new diagnosed and failed treatment) showed significantly higher methylation levels in the promoter and intron-1 regions of <i>PTPRG</i> compared to the healthy group. …”

Novel Synonymous Variant in<i> IL7R</i> Causes Preferential Expression of the Soluble Isoform by Rafah Mackeh (14151225)

“…</p><h3>Conclusion</h3><p dir="ltr">In this study, we identified a novel rare synonymous mutation causing a loss of IL-7Rα expression at the cellular membrane. This case demonstrates the value of reanalyzing genetic data based on the clinical phenotype and highlights the significance of functional studies in determining the pathogenicity of genetic variants.…”

miRNA-dependent regulation of STIM1 expression in breast cancer by Rashmi P. Kulkarni (18618634)

“…In contrast, STIM1 expression in the more aggressive basal triple-negative MDA-MB-231 cell line is not significantly modulated by a single miRNA species but is rather upregulated due to inhibition of the miRNA machinery through downregulation of Ago2. …”

Downregulation of Lymphoid enhancer‐binding factor 1 (<i>LEF‐1)</i> expression (by immunohistochemistry and/ flow cytometry) in chronic Lymphocytic Leukemia with atypical immunophe... by Dina S. Soliman (14779333)

“…The ratio for <i>LEF-1</i> expression in malignant B-cells/NK (by flow cytometry) in CLL/SLL with classic immunophenotype was higher than atypical CLL and is significantly higher in other small B-cell lymphomas (<i>P </i>< .01). …”

Cytosolic Phospholipase A2-Mediated ICAM-1 Expression Is Calcium Dependent by Abdalla, Eddie

“…Both cPLA2 and Ca2+ inhibition significantly inhibited inflammatory upregulation of ICAM-1. …”
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Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response by Noura Al-Zeheimi (5177066)

“…<i>SNAI1</i> expression in immune cells showed a significant increase (<i>p</i> = 0.018) in patients with pCR, consistent with its posited protective role. …”

Changes in Blood microRNA Expression and Early Metabolic Responsiveness 21 Days Following Bariatric Surgery by Stephen L. Atkin (6684368)

“…MicroRNA expression was determined by quantitative polymerase chain reaction and tested for significant changes after surgery.…”

A positive change in energy balance modulates TrkB expression in the hypothalamus and nodose ganglia of rats by Zeeni, Nadine

“…Adult male Wistar rats were given one of three diets for 6 weeks: high-carbohydrate, high-fat or high-fat pair-fed diets. …”
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Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy by Nassiba Taib (14557385)

“…Interestingly, in the metastatic 1872 Col cells treated with DAC, the expression of both PD-L1 and NY-ESO-1 was increased tenfold (*p = 0.0128) and fivefold (***p < 0.0001), respectively.…”

Transcriptome analysis of Escherichia coli K1 after therapy with hesperidin conjugated with silver nanoparticles by Masri, Abdulkader

“…Of note, the expression levels of cation efflux genes (cusA and copA) and translocation of ions, across the membrane genes (rsxB) were found to increase 2.6, 3.1, and 3.3- log FC, respectively. …”
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Transcriptome and Literature Mining Highlight the Differential Expression of ERLIN1 in Immune Cells during Sepsis by Susie S. Y. Huang (2824502)

“…Septic stimulation induced a significant increase in ERLIN1 expression; however, ERLIN1 was differentially expressed among the immune blood cell subsets. …”

Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway by Olfa Khalifa (10914452)

“…Additionally, after β-catenin silencing, OA treatment significantly increased the expression of nuclear transcription factors SREBP-1 and TCF4, whereas Ex-4 significantly decreased this upregulation. …”

Serum immune mediators as novel predictors of response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients with high tissue-PD-L1 expression by Afsheen Raza (492657)

“…Moreover, correlation analysis showed significant positive linear correlation of soluble PD-L1 (sPD-L1) with higher TPD-L1 expression. …”

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes by Maryam Aghadi (17128819)

“…Lack of FOXA2 resulted in significant alterations in the expression of key developmental and functional genes in hepatic progenitors (HP) and mature hepatocytes (MH) as well as an increase in the expression of ER stress markers. …”

A genome-wide DNA methylation signature for SETD1B-related syndrome by I. M. Krzyzewska (18614968)

“…<div><p>SETD1B is a component of a histone methyltransferase complex that specifically methylates Lys-4 of histone H3 (H3K4) and is responsible for the epigenetic control of chromatin structure and gene expression. …”

PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications by Pramod Darvin (153341)

“…Recent studies revealed that enhanced PD-L1 expression in cancer stem cells is linked to immune evasion. …”

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 by Olfa Khalifa (10914452)

“…Interestingly, knocking down MALAT1 significantly reduces the expression of CD36 in steatosis HepG2 cells in the presence of Ex-4. …”

Squamous Cell Carcinomas of the Head and Neck Cancer Response to Programmed Cell Death Protein-1 Targeting and Differential Expression of Immunological Markers: A Case Report by Maysaloun Merhi (4246147)

“…The PD-1 expression by the patient’s T cells was reduced 15-folds after nivolumab treatment and was uniquely restricted to the CD8+ T cells population. …”

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes by Noura Aldous (15429873)

“…To identify differentially expressed miRNAs (DEmiRs), and genes (DEGs), two differentFOXA2^–/^–iPSC lines were differentiated into PPs.FOXA2^–/^–PPs showed a significant reduction in the expression of the main PP transcription factors (TFs) in comparison to WT-PPs. …”