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Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells
Published 2011“…In this study, we investigated whether the multi-tyrosine kinase inhibitor sunitinib, effectively inhibits PDGFR signaling required for medulloblastoma cell migration. Daoy and D556 human medulloblastoma cells pre-treated for 1 h with 0.2 μM sunitinib demonstrated induction of PTEN expression and significant inhibition of PDGFR signaling activity and transactivation of EGFR, in a RAS-independent manner, in response to PDGF-BB stimulation. …”
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Exploring the Effect of [HuArgI (Co)-PEG5000]-Induced Autophagy on the Migration, Adhesion, and Invasion of A172 Glioblastoma Cells
Published 2024“…Despite this, cell migration and adhesion were reduced, with no significant reversal detected upon adding chloroquine, an autophagic flux inhibitor. …”
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Board changes and CEO turnover
Published 2014“…For firms that decrease independence, the CEO turnover performance sensitivity significantly decreases following SOX. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…<p dir="ltr">NanoLuc (NLuc) <u>luciferase</u> has found extensive application in designing a range of <u>biologica</u><u>l</u><u> assays,</u> including <u>gene expression analysis</u>, protein-protein interaction, and protein conformational changes due to its enhanced brightness and small size. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Global gene expression profiling of LY411575-treated cells revealed changes in multiple signaling pathways, including focal adhesion, insulin, TGFβ, IL6, and Notch signaling, and decreased the expression of genes associated with functional categories of tissue development. …”
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Vocal Changes in Patients With Polycystic Ovary Syndrome
Published 2011“…There was no statistically significant difference in the acoustic parameters except for an increase in the relative average perturbation (P value = 0.035) and a decrease in maximum phonation time (P value = 0.001) in patients with PCOS. …”
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Tumorigenic proteins upregulated in the MYCN-amplified IMR-32 human neuroblastoma cells promote proliferation and migration
Published 2018“…The early apoptotic rates were significantly higher in the IMR-32 cells in which FABP5 and MYCN were knocked down, whereas cellular migration was significantly abrogated with FABP5 and HMGA1 KD compared to the controls. …”
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Essays on the effect of excess compensation and governance changes on firm value
Published 2012“…This dissertation consists of three essays on the effect of excess compensation and corporate governance changes on the firm’s performance. The first paper utilizes a cost minimization stochastic frontier approach to investigate the efficiency of director total compensation. …”
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Metabolomics of Dynamic Changes in Insulin Resistance Before and After Exercise in PCOS
Published 2019“…While compering within the groups, no significant changes in the amino acid levels before and after exercise were observed. …”
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Conceptual Skills in Leading Change: A Competence Approach to Public Sector Leadership
Published 2019“…Leaders’ capacity to think about abstract and complex ideas has long been acknowledged as essential to leadership tasks such as planning and analysis; however, because conceptualisation is often ambiguous and difficult to understand, many frameworks of leadership and change lack clarity on the actual significance of leaders’ conceptual skills when leading change. …”
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Swimming exercise improves short‐ and long‐term memories: Time‐course changes
Published 2021“…In this investigation, changes in the spatial hippocampal memory following a time-course of swimming exercise training were examined. …”
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Exploring urban growth–climate change–flood risk nexus in fast growing cities
Published 2022“…In addition, Doha witnessed various climatic changes with a notable increase in air temperature (+ 8.7%), a decrease in surface wind speed (− 19.5%), and a decrease in potential evapotranspiration losses (− 33.5%). …”
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The impact of COVID‐19 pandemic lockdown on smoking habits and lifestyle: A cross‐sectional study
Published 2023“…Most of our sample's smoker participants experienced a change in their smoking level mostly, an increase. …”
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Changes in Blood microRNA Expression and Early Metabolic Responsiveness 21 Days Following Bariatric Surgery
Published 2019“…MicroRNA expression was determined by quantitative polymerase chain reaction and tested for significant changes after surgery.</p><p dir="ltr"><br></p><h3>Results: </h3><p dir="ltr">BMI decreased by 3.8 kg/m<sup>2</sup> 21 days postoperatively. …”
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Brain microstructural changes support cognitive deficits in HIV uninfected children born to HIV infected mothers
Published 2020“…ResultsHIC and HUC groups showed significantly decreased NP test scores in various domain compared to CHNM. …”
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