Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis by Iman Abdelaziz Mohamed (18102700)

A multi-targeted approach to identify potential flavonoids against three targets in the SARS-CoV-2 life cycle by Sanjay Kumar (8853)

“…</p><p dir="ltr">In contrast, hesperidin formed a more significant number of hydrogen bonds with PLpro. These observations were complimented by the 100 ns molecular dynamics simulation and binding free energy analysis, which showed a considerable stability of docked bioflavonoids in the active site of SARS-CoV-2 target proteins. …”

PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer by Caroline Spasojevic (3619418)

“…Together, these results establish PKD1 as a poor prognostic factor and a potential therapeutic target in TNBC.</p><h2>Other Information</h2><p dir="ltr">Published in: Oncotarget<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.18632/oncotarget.25292" target="_blank">https://dx.doi.org/10.18632/oncotarget.25292</a></p>…”

Novel insights into the potential role of ion transport in sensory perception in Acanthamoeba by Siddiqui, Ruqaiyyah

“…Conclusions: The present study indicates that ion transporters are involved in sensory perception of A. castellanii suggesting their value as potential therapeutic targets to block cellular differentiation that presents a significant challenge in the successful prognosis of Acanthamoeba infections.…”
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Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity by Mohamed Abu-Farha (18535590)

“…HDAC4 could therefore represent a potential therapeutic target for the control and management of obesity and presumably insulin resistance.…”

Enhancing Curcumin’s therapeutic potential in cancer treatment through ultrasound mediated liposomal delivery by Radha, Remya

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Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy by Remy Thomas (702843)

“…This restricted expression pattern together with the important role of LDHC in cancer metabolism renders LDHC a potential target for immunotherapy. This study is the first to investigate the immunogenicity of LDHC using T cells from healthy individuals. …”

Role of Exosome in Solid Cancer Progression and Its Potential Therapeutics in Cancer Treatment by Nada Aakel (18877111)

“…These vesicles activate oncogenic pathways and can serve as biomarkers or therapeutic targets due to their role in disease modulation.</p><h3>Conclusion</h3><p dir="ltr">Exosomes play a pivotal role in solid cancer progression and offer significant potential in advancing our understanding of tumor biology. …”

Board changes and CEO turnover by Dah, Mustafa A.

“…For firms that decrease independence, the CEO turnover performance sensitivity significantly decreases following SOX. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…<p dir="ltr">NanoLuc (NLuc) <u>luciferase</u> has found extensive application in designing a range of <u>biologica</u><u>l</u><u> assays,</u> including <u>gene expression analysis</u>, protein-protein interaction, and protein conformational changes due to its enhanced brightness and small size. …”

Extracellular vesicles as tools and targets in therapy for diseases by Mudasir A. Kumar (21633080)

“…Especially in cancer diagnostics, EV detection can pave the way for early identification and offers potential as diagnostic biomarkers. Moreover, various EV subtypes are emerging as targeted drug delivery tools, highlighting their potential clinical significance. …”

Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy by Adviti Naik (673163)

“…This study supports the therapeutic potential of targeting LDHC to mitigate cancer cell survival and improve sensitivity to agents that cause DNA damage or inhibit its repair.…”

Potential Medical Applications of Chitooligosaccharides by Sukumaran Anil (14158935)

“…</p><h2>Other Information</h2><p dir="ltr">Published in: Polymers<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/polym14173558" target="_blank">https://dx.doi.org/10.3390/polym14173558</a></p>…”

Claudins in ovarian cancer: emerging biomarkers and therapeutic targets by Lubna Therachiyil (4246156)

“…These elevated expression observed among OC subtypes indicates their potential utility as diagnostic biomarkers. Claudins represent potential targets for innovative therapeutic strategies. …”

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…Global gene expression profiling of LY411575-treated cells revealed changes in multiple signaling pathways, including focal adhesion, insulin, TGFβ, IL6, and Notch signaling, and decreased the expression of genes associated with functional categories of tissue development. …”

Vocal Changes in Patients With Polycystic Ovary Syndrome by Hannoun, Antoine

“…There was no statistically significant difference in the acoustic parameters except for an increase in the relative average perturbation (P value = 0.035) and a decrease in maximum phonation time (P value = 0.001) in patients with PCOS. …”
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Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases by Mazhar Pasha (11197767)

“…As perturbations in the aforementioned pathways are well documented in multiple diseases, Sestrin2 might serve as a potential therapeutic target for various diseases. …”

Pharmacological interventions targeting β-adrenoceptors in colorectal cancer: an evolving paradigm by Aya Ghosn (22997230)

“…<p dir="ltr">Colorectal cancer (CRC) is a significant global health challenge, ranking as the third most common cancer and the second leading cause of cancer-related deaths worldwide. …”

In Vitro Cell Work of Two Types of Targeted Nanoparticles with Ultrasound Triggering by Abuwatfa, Waad Hussein

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Molecular Profiling Reveals Limited Targetable Biomarkers in Neuroendocrine Carcinoma of the Cervix by Adela Cimic (14908512)

“…<p>Neuroendocrine carcinoma of the cervix (NEC) is a rare and highly aggressive cervical malignancy. Given that no targeted therapy has been approved specifically to NEC, we investigated the presence of novel, potentially targetable biomarkers in a large cohort of NEC. …”