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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Construction workforce management strategies to reduce absenteeism
Published 2014“…Despite the international location of the survey, the results indicate a worker demographic similar to that found in the southwestern United States and other areas with significant residential construction. The results also serve to highlight the significance of basic management techniques in reducing absenteeism: adopting training programs to increase the skill level of workers, providing incentives to increase the tenure of workers onsite, and arranging the working schedule to favor less overtime.…”
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Motivated & Engaged: Leveraging Gamification to Reduce Employee Burnout
Published 2025“…Gamification can serve as a non-monetary motivational lever to boost engagement, enhance productivity, and reduce turnover-related costs. Originality/value – This research adds to the limited empirical evidence on gamification in emerging markets by validating its moderating role in reducing burnout. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Reduced graphene aerogels as energy efficient selective oil sorbents
Published 2022“…The presence of H<sub>2</sub> significantly decreased the oxygen-containing functional groups in graphene aerogel. …”
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Comparative cost assessment of sustainable energy carriers produced from natural gas accounting for boil-off gas and social cost of carbon
Published 2020“…DME and methanol can be more economic compared to LNG to transport the energy of natural gas for the same ship capacity. Including social cost of carbon (SCC) within the total cost of transporting the energy of natural gas, the transportation cost of liquid ammonia is 1.11 $/GJ, whereas LNG transportation cost rises significantly to 1.68 $/GJ at SCC of 137 $/t CO<sub>2</sub> eq. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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A Study on Reducing Heat Gains through the use of Green Envelope
Published 2013“…The usage of green roof and living walls in high rise building reduced the cooling loads by 24.35% comparing to the base case. …”
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